SCHEMBL6589460

SCHEMBL6589460

Cc1c(-c2cc3cc(OCc4ccc(Cl)cc4)ccc3o2)oc(=O)c(C)c1O

nearest known ligand 0.55

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MAOB P27338 15/20 0.55
MAOA P21397 9/20 0.55
ACHE P22303 7/20 0.55
SLC26A4 O43511 1/20 0.49
KMT2A Q03164 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6590949 0.92 MAOB (0.58) MAOBMAOAACHE
SCHEMBL6595476 0.92 MAOB (0.47) MAOBMAOAACHESLC26A4KMT2A
SCHEMBL6593950 0.91 NPC1 (0.48) MAOBMAOAACHEKMT2A
SCHEMBL6596674 0.90 MEN1 (0.51) MAOBMAOAACHESLC26A4KMT2A
SCHEMBL6593795 0.90 MAOB (0.55) MAOBMAOAACHE
SCHEMBL6591398 0.90 MAOB (0.54) MAOBMAOAACHEKMT2A
SCHEMBL6593695 0.89 MAOB (0.59) MAOBMAOAACHESLC26A4KMT2A
SCHEMBL6591035 0.89 MAOB (0.44) MAOBMAOAACHE
SCHEMBL6594358 0.88 S1PR1 (0.45) MAOBMAOAACHE
SCHEMBL6591739 0.88 KMT2A (0.49) MAOBMAOAACHESLC26A4KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1063235-B1 BENZOFURYLPYRONE DERIVATIVES TEIJIN LTD (JP) 2004-05-12 EP disclosed
US-20030186976-A1 Benzofurylpyrone derivatives TEIJIN LIMITED, MICROBIAL CHEMISTRY RESEARCH FOUNDATION 2003-10-02 US disclosed
US-6589984-B1 Blood cholesterol and triglycerides (TG) themselves are generally insoluble in blood, and they exist as lipoproteins by binding with apolipoproteins. In the body, triglycerides are biosynthesized primarily in the liver from acetyl CoA as TEIJIN LIMITED (JP) 2003-07-08 US disclosed
EP-1063235-A1 BENZOFURYLPYRONE DERIVATIVES TEIJIN LIMITED (JP) 2000-12-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030186976-A1 Benzofurylpyrone derivatives PLIN5, ACSL5, PLIN1 MAOB 3367/4885MAOA 4187/4885ACHE 4708/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.