Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 9/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 9/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4889259 | 0.96 | KEAP1 (0.51) | KEAP1NFE2L2CHRM2CHRM3MAPT | |
| SCHEMBL9193099 | 0.95 | MAPT (0.52) | KEAP1NFE2L2CHRM2CHRM3MAPT | |
| SCHEMBL609929 | 0.92 | MEN1 (0.43) | KEAP1NFE2L2CHRM2CHRM3MAPT | |
| SCHEMBL552275 | 0.78 | MEN1 (0.36) | KEAP1NFE2L2CHRM2CHRM3MAPT | |
| SCHEMBL2062914 | 0.78 | KEAP1 (0.56) | KEAP1NFE2L2CHRM2CHRM3MAPT | |
| SCHEMBL2062409 | 0.78 | KEAP1 (0.56) | KEAP1NFE2L2CHRM2CHRM3MAPT | |
| SCHEMBL27700604 | 0.76 | KEAP1 (0.54) | KEAP1NFE2L2CHRM2CHRM3MAPT | |
| SCHEMBL27821813 | 0.76 | KEAP1 (0.54) | KEAP1NFE2L2CHRM2CHRM3MAPT | |
| SCHEMBL12531908 | 0.76 | MAPT (0.52) | KEAP1NFE2L2CHRM2CHRM3MAPT | |
| SCHEMBL198459 | 0.76 | MAPT (0.52) | KEAP1NFE2L2CHRM2CHRM3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823423-B1 | 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2004-06-16 | — | — | EP | disclosed |
| US-5750540-A | SIDE EFFECT REDUCTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-05-12 | — | — | US | disclosed |
| EP-0823423-A1 | 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-02-11 | — | — | EP | disclosed |
| EP-0486734-A1 | 1-Aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders | MARION MERRELL DOW INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5001160-A | 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders | MARION LABORATORIES, INC. (US) | 1991-03-19 | — | — | US | disclosed |