Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 17/20 | 0.78 |
| ▸ | CHRM3 known ✓ | P20309 | 17/20 | 0.78 |
| ▸ | CHRM1 | P11229 | 17/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6589809 | 1.00 | CHRM2 (0.78) | CHRM2CHRM1CHRM3 | |
| SCHEMBL6590099 | 0.95 | CHRM2 (0.82) | CHRM2CHRM1CHRM3 | |
| SCHEMBL6589599 | 0.94 | CHRM2 (0.79) | CHRM2CHRM1CHRM3 | |
| Fumaric Acid SCHEMBL6587545 | 0.92 | CHRM2 (0.93) | CHRM2CHRM1CHRM3 | |
| Fumaric Acid SCHEMBL6587535 | 0.92 | CHRM2 (0.93) | CHRM2CHRM1CHRM3 | |
| Fumaric Acid SCHEMBL27496757 | 0.92 | CHRM2 (0.93) | CHRM2CHRM1CHRM3 | |
| Fumaric Acid SCHEMBL6589985 | 0.90 | CHRM2 (0.89) | CHRM2CHRM1CHRM3 | |
| Fumaric Acid SCHEMBL27482727 | 0.90 | CHRM2 (0.89) | CHRM2CHRM1CHRM3 | |
| Fumaric Acid SCHEMBL6589977 | 0.90 | CHRM2 (0.89) | CHRM2CHRM1CHRM3 | |
| SCHEMBL508756 | 0.88 | CHRM2 (1.00) | CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823423-B1 | 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2004-06-16 | — | — | EP | disclosed |
| US-5750540-A | SIDE EFFECT REDUCTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-05-12 | — | — | US | disclosed |
| EP-0823423-A1 | 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-02-11 | — | — | EP | disclosed |