Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | RAB9A | P51151 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | SMO | Q99835 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | OGA | O60502 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400408 | 0.88 | KMT2A (0.58) | KMT2ANPC1RAB9AMEN1SMO | |
| SCHEMBL9211056 | 0.84 | KMT2A (1.00) | KMT2ANPC1RAB9AMEN1ATM | |
| SCHEMBL31352228 | 0.83 | UBE2T (0.58) | KMT2ANPC1RAB9ASMOALDH1A1 | |
| SCHEMBL19836997 | 0.83 | UBE2T (0.58) | KMT2ANPC1RAB9ASMOALDH1A1 | |
| SCHEMBL1989630 | 0.83 | UBE2T (0.63) | KMT2ANPC1RAB9ASMOALDH1A1 | |
| SCHEMBL29784322 | 0.83 | UBE2T (0.63) | KMT2ANPC1RAB9ASMOALDH1A1 | |
| SCHEMBL18923057 | 0.83 | SMO (0.53) | KMT2ANPC1RAB9AMEN1SMO | |
| SCHEMBL2305342 | 0.83 | RAB9A (0.59) | KMT2ANPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL63778 | 0.83 | ALDH1A1 (0.73) | KMT2ANPC1RAB9AALDH1A1MAPT | |
| SCHEMBL1329870 | 0.83 | RAB9A (0.58) | KMT2ANPC1RAB9ASMOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |