Sugi Predict

Sugi Predict / Compounds / SCHEMBL63778

SCHEMBL63778

SCHEMBL63778

O=C(O)c1ccc(N2CCOCC2)nc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.73
▸ POLB P06746 2/20 0.68
▸ HPGD P15428 2/20 0.68
▸ HSD17B10 Q99714 2/20 0.68
▸ KDM4E B2RXH2 1/20 0.68
▸ ALOX15 P16050 1/20 0.68
▸ PIK3CA P42336 1/20 0.61
▸ MAPT P10636 3/20 0.56
▸ SMN1; SMN2 Q16637 2/20 0.56
▸ CYP1A2 P05177 2/20 0.56
▸ CYP2C19 P33261 1/20 0.56
▸ LMNA P02545 1/20 0.56
▸ HTT P42858 1/20 0.56
▸ STAT3 P40763 1/20 0.54
▸ CYP2C9 P11712 1/20 0.54
▸ KCNQ3 O43525 1/20 0.53
▸ KCNQ2 O43526 1/20 0.53
▸ AKR1C3 P42330 1/20 0.52
▸ USP30 Q70CQ3 1/20 0.52
▸ KMO O15229 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL19119306 0.98 ALDH1A1 (0.71) ALDH1A1POLBHPGDHSD17B10KDM4E
SCHEMBL2129780 0.94 ALDH1A1 (0.66) ALDH1A1POLBHPGDHSD17B10KDM4E
SCHEMBL19160257 0.86 ALDH1A1 (0.71) ALDH1A1POLBHPGDHSD17B10KDM4E
SCHEMBL243892 0.86 ALDH1A1 (0.71) ALDH1A1POLBHPGDHSD17B10KDM4E
SCHEMBL31283651 0.86 ALDH1A1 (0.71) ALDH1A1POLBHPGDHSD17B10KDM4E
SCHEMBL357927 0.86 ALDH1A1 (0.71) ALDH1A1POLBHPGDHSD17B10KDM4E
SCHEMBL209882 0.86 ALDH1A1 (0.71) ALDH1A1POLBHPGDHSD17B10KDM4E
SCHEMBL2974981 0.86 ALDH1A1 (0.71) ALDH1A1POLBHPGDHSD17B10KDM4E
SCHEMBL4434941 0.85 ALDH1A1 (0.66) ALDH1A1POLBHPGDHSD17B10KDM4E
SCHEMBL1989630 0.85 UBE2T (0.63) ALDH1A1POLBHPGDHSD17B10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 361 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4737449-A1 P53-Y220C SELECTIVE SMALL-MOLECULAR REACTIVATOR COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF Changchun Genescience Pharmaceutical Co., Ltd. (CN) 2026-05-06 — — EP disclosed
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-05-13 — — US disclosed
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-04-08 — — US disclosed
WO-2025002177-A1 P53-Y220C SELECTIVE SMALL-MOLECULAR REACTIVATOR COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF 长春金赛药业有限责任公司 2025-01-02 — — WO disclosed
US-20240360155-A1 Benzodiazepine Derivatives as RSV Inhibitors ENANTA PHARM INC (US) 2024-10-31 — — US disclosed
CN-118119411-A Peptide dendrimers and methods of use thereof 阿斯利康(瑞典)有限公司 2024-05-31 — — CN disclosed
US-11952389-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2024-04-09 — — US disclosed
EP-3687543-B1 COMBINATIONS OF PHARMACEUTICAL AGENTS AS RSV INHIBITORS ENANTA PHARM INC (US) 2024-03-20 — — EP disclosed
US-11702652-B2 Enzymatic encoding methods for efficient synthesis of large libraries NUEVOLUTION A/S (DK) 2023-07-18 — — US disclosed
US-11702652-B2 Enzymatic encoding methods for efficient synthesis of large libraries NUEVOLUTION A/S (DK) 2023-07-18 — — US disclosed
US-6417185-B1 HETEROCYCLIC ENZYME INHIBITORS CHIRON CORPORATION 2002-07-09 — — US disclosed
EP-1187613-A1 AMIDE SUBSTITUTED IMIDAZOQUINOLINES 3M Innovative Properties Company (US) 2002-03-20 — — EP disclosed
WO-2002020495-A2 INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 CHIRON CORPORATION (US) 2002-03-14 — — WO disclosed
CN-1312807-A Inhibitors of glycogen synthase kinase 3 CHIRON CORP (US) 2001-09-12 — — CN disclosed
EP-1087963-A1 INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 Chiron Corporation (US) 2001-04-04 — — EP disclosed
US-6194425-B1 VIRICIDES, ANTITUMOR AGENTS 3M INNOVATIVE PROPERTIES COMPANY 2001-02-27 — — US disclosed
WO-2000076505-A1 AMIDE SUBSTITUTED IMIDAZOQUINOLINES 3M INNOVATIVE PROPERTIES COMPANY (US) 2000-12-21 — — WO disclosed
EP-1040112-A1 IMIDAZONAPHTHYRIDINES AND THEIR USE IN INDUCING CYTOKINE BIOSYNTHESIS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 2000-10-04 — — EP disclosed
WO-1999065897-A1 INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 CHIRON CORPORATION (US) 1999-12-23 — — WO disclosed
WO-1999029693-A1 IMIDAZONAPHTHYRIDINES AND THEIR USE IN INDUCING CYTOKINE BIOSYNTHESIS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1999-06-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240360155-A1 Benzodiazepine Derivatives as RSV Inhibitors GABRA5, GABRA1, GABBR2 ALDH1A1 621/4885POLB 4513/4885HPGD 869/4885
US-11952389-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 ALDH1A1 621/4885POLB 4513/4885HPGD 869/4885
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 ALDH1A1 621/4885POLB 4513/4885HPGD 869/4885
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ACE, ACE2, SPCS3 ALDH1A1 4172/4885POLB 3210/4885HPGD 2245/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.