Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | GLA | P06280 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6591011 | 1.00 | MAPT (0.54) | MAPTMEN1KMT2AGLAHTT | |
| SCHEMBL7381862 | 0.95 | ALDH1A1 (0.56) | MAPTMEN1KMT2AGLAHTT | |
| SCHEMBL7375198 | 0.93 | MAPT (0.49) | MAPTMEN1KMT2AGLAHTT | |
| SCHEMBL6981759 | 0.86 | TLR9 (0.53) | MAPTMEN1KMT2AGLAHTT | |
| SCHEMBL6981756 | 0.86 | TLR9 (0.53) | MAPTMEN1KMT2AGLAHTT | |
| SCHEMBL6588014 | 0.85 | ALDH1A1 (0.57) | MAPTGLAHTTALDH1A1TLR9 | |
| SCHEMBL6588022 | 0.85 | ALDH1A1 (0.57) | MAPTGLAHTTALDH1A1TLR9 | |
| SCHEMBL8393177 | 0.82 | TLR9 (0.51) | MAPTMEN1KMT2AGLAHTT | |
| SCHEMBL6980279 | 0.80 | FDPS (0.51) | MAPTMEN1KMT2AALDH1A1TLR9 | |
| SCHEMBL6980282 | 0.80 | FDPS (0.51) | MAPTMEN1KMT2AALDH1A1TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150977-B1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-08-25 | — | — | EP | disclosed |
| US-6699879-B1 | OBESITY, DIABETES, SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-03-02 | — | — | US | disclosed |