Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981756 | 1.00 | TLR9 (0.53) | TLR9LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1531401 | 0.89 | TYR (0.58) | LMNASMN1; SMN2ALDH1A1MAPTHTT | |
| SCHEMBL1531400 | 0.89 | TYR (0.58) | LMNASMN1; SMN2ALDH1A1MAPTHTT | |
| SCHEMBL6588014 | 0.87 | ALDH1A1 (0.57) | TLR9LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6588022 | 0.87 | ALDH1A1 (0.57) | TLR9LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6980279 | 0.87 | FDPS (0.51) | TLR9LMNAALDH1A1MAPTTDP1 | |
| SCHEMBL6980282 | 0.87 | FDPS (0.51) | TLR9LMNAALDH1A1MAPTTDP1 | |
| SCHEMBL16971083 | 0.87 | TLR9 (0.49) | TLR9LMNAALDH1A1MAPTHTT | |
| SCHEMBL6591011 | 0.86 | MAPT (0.54) | TLR9LMNAALDH1A1MAPTHTT | |
| SCHEMBL6591007 | 0.86 | MAPT (0.54) | TLR9LMNAALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839806-B1 | Substituted tricyclics | LILLY CO ELI (US) | 2003-07-09 | — | — | EP | disclosed |
| WO-1998018464-A1 | SUBSTITUTED TRICYCLICS | ELI LILLY AND COMPANY (US) | 1998-05-07 | — | — | WO | disclosed |
| EP-0839806-A1 | Substituted tricyclics | ELI LILLY AND COMPANY (US) | 1998-05-06 | — | — | EP | disclosed |