Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952352 | 0.87 | MEN1 (0.38) | MEN1ALDH1A1KMT2ATDP1 | |
| SCHEMBL15915417 | 0.74 | HTR7 (0.42) | ALDH1A1CA1CA2CA4CA6 | |
| SCHEMBL31303112 | 0.74 | AOC3 (0.42) | PRKDCCA1CA2 | |
| SCHEMBL20570782 | 0.74 | MEN1 (0.31) | MEN1ALDH1A1KMT2A | |
| SCHEMBL25234795 | 0.74 | AOC3 (0.42) | PRKDCCA1CA2 | |
| SCHEMBL610877 | 0.73 | ALDH1A1 (0.48) | ERN1MEN1ALDH1A1KMT2ATDP1 | |
| SCHEMBL28753820 | 0.73 | ALDH1A1 (0.33) | ERN1MEN1ALDH1A1KMT2ATDP1 | |
| SCHEMBL658069 | 0.71 | CYP2A6 (0.38) | ERN1MEN1ALDH1A1KMT2ATDP1 | |
| SCHEMBL28941890 | 0.71 | MEN1 (0.36) | ERN1MEN1ALDH1A1KMT2ATDP1 | |
| SCHEMBL6934720 | 0.71 | AOC3 (0.37) | MEN1ALDH1A1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8378104-B2 | 7-aminofuropyridine derivatives | OSI Pharmaceuticals, LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-20120046267-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | OSI PHARMACEUTICALS, INC. | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046267-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | MAP3K5, STK17A, MAPKAPK5 | ERN1 1589/4885MEN1 296/4885ALDH1A1 490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.