Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 9/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.32 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.32 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.32 |
| ▸ | MDM4 | O15151 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL661650 | 0.86 | KDM1A (0.32) | KDM1A | |
| SCHEMBL659170 | 0.82 | PDE4B (0.38) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL661285 | 0.75 | PDE4D (0.46) | PDE4APDE4BPDE4DPDE4CHIF1A | |
| SCHEMBL661555 | 0.67 | PDE4B (0.45) | PDE4APDE4BPDE4DPDE4CHIF1A | |
| SCHEMBL661651 | 0.65 | CYP3A4 (0.35) | KDM1APDE4APDE4BPDE4DPDE4C | |
| SCHEMBL14042199 | 0.65 | HIF1A (0.46) | PDE4APDE4BPDE4DPDE4CHIF1A | |
| SCHEMBL658699 | 0.64 | PDE4D (0.43) | PDE4APDE4BPDE4DPDE4CHIF1A | |
| SCHEMBL662935 | 0.63 | CYP3A4 (0.49) | PDE4APDE4BPDE4DPDE4CHIF1A | |
| SCHEMBL10106834 | 0.63 | HIF1A (0.35) | PDE4APDE4BPDE4DPDE4CHIF1A | |
| SCHEMBL24812331 | 0.62 | FDPS (0.49) | PDE4BHIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8536157-B2 | Non-steroidal compounds | THE UNIVERSITY OF MELBOURNE (AU) | 2013-09-17 | — | — | US | disclosed |
| US-20120046255-A1 | NON-STEROIDAL COMPOUNDS | THE UNIVERSITY OF MELBOURNE of ROYAL PARADE PARKVILLE (AU) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046255-A1 | NON-STEROIDAL COMPOUNDS | PTGES2, PTGES, PTGES3 | KDM1A 4739/4885PDE4A 561/4885PDE4B 823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.