Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SNCA | P37840 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6593962 | 1.00 | KDM4E (0.51) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL6591136 | 1.00 | KDM4E (0.51) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL11619942 | 0.82 | KDM4E (0.70) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL6589327 | 0.75 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL18196230 | 0.70 | CASP3 (0.55) | KDM4EALDH1A1HPGDHTTAPP | |
| SCHEMBL15267393 | 0.69 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL28373918 | 0.68 | ITGA4 (0.49) | KDM4EALDH1A1HPGDAPPMAPT | |
| SCHEMBL2348974 | 0.68 | CES1 (0.73) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL4649471 | 0.68 | KMT2A (0.78) | ALDH1A1HTTKMT2AMEN1SCN2A | |
| SCHEMBL30089821 | 0.67 | ALDH1A1 (0.70) | KDM4EALDH1A1HPGDSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703232-B1 | 2,3-Dihydro-1H-isoindole derivates, a process for their preparation and their use as serotonin reuptake inhibitors | AVENTIS PHARMA INC (US) | 2004-06-30 | — | — | EP | claimed |