Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8660419 | 0.88 | CA2 (0.43) | CA2HDAC3HDAC1HDAC2SSTR4 | |
| SCHEMBL8650317 | 0.81 | CA2 (0.49) | CA2HDAC3HDAC1HDAC2SSTR4 | |
| SCHEMBL6464770 | 0.74 | CA2 (0.49) | CA2HDAC3HDAC1HDAC2SSTR4 | |
| SCHEMBL6591026 | 0.74 | CA2 (0.56) | CA2SSTR4NISCHCA1HTR1A | |
| SCHEMBL6591968 | 0.74 | CA2 (0.44) | CA2HDAC3HDAC1HDAC2SSTR4 | |
| SCHEMBL8650607 | 0.74 | CA2 (0.47) | CA2HDAC3HDAC1HDAC2SSTR4 | |
| SCHEMBL8650215 | 0.73 | CA2 (0.46) | CA2HDAC3HDAC1HDAC2SSTR4 | |
| Acetic Acid SCHEMBL27984668 | 0.71 | CA2 (0.44) | CA2HDAC3HDAC1HDAC2SSTR4 | |
| SCHEMBL4672085 | 0.71 | CA2 (0.49) | CA2HDAC3HDAC1HDAC2SSTR4 | |
| SCHEMBL5695491 | 0.70 | HDAC3 (0.49) | CA2HDAC3HDAC1HDAC2NISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842927-B1 | 3-Amido-chromanylsulfonyl(thio)ureas, process for their preparation, their use and medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-02-25 | — | — | EP | claimed |
| EP-0779288-B1 | Substituted chromanylsulfonyl(thio)ureas, process for their preparation, their use in pharmaceutical compositions and preparations containing them | HOECHST AG (DE) | 2000-03-29 | — | — | EP | claimed |
| US-5849755-A | 3-amidochromanylsulfonyl(thio)ureas, processes for their preparation, their use, and pharmaceutical preparations comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-12-15 | — | — | US | claimed |
| US-5811448-A | PHARMACEUTICALS USEFUL FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-22 | — | — | US | claimed |
| CN-1158272-C | Substituted benzodihydropyranyl sulfonylurea, its preparation, use in medicines and the medicines containing the same | �ճ�˹�عɷݹ�˾ | 2004-07-21 | — | — | CN | disclosed |
| EP-0779288-B1 | Substituted chromanylsulfonyl(thio)ureas, process for their preparation, their use in pharmaceutical compositions and preparations containing them | HOECHST AG (DE) | 2000-03-29 | — | — | EP | disclosed |
| US-5849755-A | 3-amidochromanylsulfonyl(thio)ureas, processes for their preparation, their use, and pharmaceutical preparations comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-12-15 | — | — | US | disclosed |
| US-5811448-A | PHARMACEUTICALS USEFUL FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-22 | — | — | US | disclosed |
| US-5811448-A | PHARMACEUTICALS USEFUL FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-22 | — | — | US | disclosed |
| CN-1155545-A | Substituted benzodihydropyranyl sulfonylurea, its preparation, use in medicines and the medicines containing the same | HOECHST AG (DE) | 1997-07-30 | — | — | CN | disclosed |
| EP-0779288-A1 | Substituted chromanylsulfonyl(thio)ureas, process for their preparation, their use in pharmaceutical compositions and preparations containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-06-18 | — | — | EP | disclosed |