Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.49 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8650607 | 0.89 | CA2 (0.47) | CA2SSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL8650215 | 0.89 | CA2 (0.46) | CA2SSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL6591970 | 0.81 | CA2 (0.45) | CA2SSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL6464770 | 0.79 | CA2 (0.49) | CA2SSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL6591026 | 0.79 | CA2 (0.56) | CA2SSTR4NISCHCA1HTR1A | |
| SCHEMBL6591968 | 0.78 | CA2 (0.44) | CA2SSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL9662181 | 0.77 | CA2 (0.47) | CA2NISCHMEN1KMT2AHTR1A | |
| Acetic Acid SCHEMBL27984668 | 0.75 | CA2 (0.44) | CA2SSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL4672085 | 0.75 | CA2 (0.49) | CA2SSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL10664459 | 0.74 | MEN1 (0.36) | CA2HDAC3HDAC1HDAC2NISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849755-A | 3-amidochromanylsulfonyl(thio)ureas, processes for their preparation, their use, and pharmaceutical preparations comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-12-15 | — | — | US | disclosed |
| US-5811448-A | PHARMACEUTICALS USEFUL FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-22 | — | — | US | disclosed |