⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19435489 | 0.72 | CYP19A1 (0.38) | — | |
| SCHEMBL660030 | 0.72 | SLC22A12 (0.38) | — | |
| SCHEMBL12260048 | 0.64 | CYP2A6 (0.33) | — | |
| SCHEMBL16180524 | 0.64 | CYP2A6 (0.33) | — | |
| SCHEMBL657782 | 0.60 | ALDH1A1 (0.33) | — | |
| SCHEMBL658867 | 0.60 | — | — | |
| SCHEMBL910839 | 0.58 | KDM4E (0.39) | — | |
| SCHEMBL1594696 | 0.58 | NOS1 (0.39) | — | |
| SCHEMBL5439074 | 0.58 | CYP3A4 (0.39) | — | |
| SCHEMBL29949378 | 0.57 | POLB (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8378104-B2 | 7-aminofuropyridine derivatives | OSI Pharmaceuticals, LLC (US) | 2013-02-19 | — | — | US | disclosed |
| EP-2534156-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | OSI Pharmaceuticals, LLC (US) | 2012-12-19 | — | — | EP | disclosed |
| US-20120046267-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | OSI PHARMACEUTICALS, INC. | 2012-02-23 | — | — | US | disclosed |
| WO-2011100502-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | OSI Pharmaceuticals, LLC (US) | 2011-08-18 | — | — | WO | disclosed |