Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 2/20 | 0.53 |
| ▸ | OXTR | P30559 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27401270 | 0.92 | AVPR1A (0.43) | AVPR1ATSHRCYP2C9HTTATM | |
| SCHEMBL4879878 | 0.75 | AVPR1A (0.49) | AVPR1AOXTRSMN1; SMN2CYP2C9HTT | |
| SCHEMBL24890358 | 0.73 | AVPR1A (0.58) | AVPR1AOXTRTSHRSMN1; SMN2HPGD | |
| SCHEMBL8669619 | 0.73 | AVPR1A (0.46) | AVPR1AOXTRSMN1; SMN2HPGDHTT | |
| SCHEMBL5823683 | 0.72 | AVPR1A (0.49) | AVPR1AOXTRSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL6547461 | 0.72 | AVPR1A (0.45) | AVPR1AOXTRTSHRSMN1; SMN2HTT | |
| SCHEMBL7995092 | 0.72 | HDAC1 (0.38) | HPGDPTGS2APPALDH1A1KDM4E | |
| SCHEMBL474103 | 0.71 | HPGDS (0.51) | ATMALDH1A1CYP1A2HSD17B10CYP3A4 | |
| SCHEMBL13713425 | 0.70 | AVPR1A (0.48) | AVPR1ATSHRSMN1; SMN2HPGDCYP2C9 | |
| Iodide SCHEMBL29040394 | 0.69 | AVPR1A (0.47) | AVPR1ATSHRSMN1; SMN2HPGDCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474417-A2 | PROCESSES FOR PREPARING LOSARTAN AND LOSARTAN POTASSIUM | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003093262-A2 | PROCESSES FOR PREPARING LOSARTAN AND LOSARTAN POTASSIUM | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2003-11-13 | — | — | WO | disclosed |