Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377100 | 0.82 | MAPT (0.60) | L3MBTL1LMNAKDM4EMAPK1TDP1 | |
| SCHEMBL9566443 | 0.74 | BRD4 (0.57) | BRD4L3MBTL1MAPK1TDP1MAPT | |
| SCHEMBL27032689 | 0.74 | LMNA (0.51) | LMNAMAPK1TSHRHTTMEN1 | |
| SCHEMBL7464316 | 0.73 | BRD4 (0.59) | BRD4L3MBTL1KDM4EMAPK1TDP1 | |
| SCHEMBL7939339 | 0.73 | ALDH1A1 (0.51) | LMNAKDM4ETDP1MAPTHTT | |
| SCHEMBL9397429 | 0.72 | BRD4 (0.59) | BRD4L3MBTL1KDM4EMAPK1TDP1 | |
| SCHEMBL26013299 | 0.72 | MAPT (0.63) | BRD4L3MBTL1MAPK1TDP1MAPT | |
| SCHEMBL29502771 | 0.70 | MAPT (0.58) | BRD4L3MBTL1MAPK1TDP1MAPT | |
| SCHEMBL14813470 | 0.70 | MAPT (0.58) | BRD4L3MBTL1MAPK1TDP1MAPT | |
| SCHEMBL659166 | 0.70 | MAPT (0.50) | BRD4L3MBTL1LMNAMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781766-B1 | HETEROCYCLIC DERIVATIVE AND MEDICINE | NIPPON SHINYAKU CO LTD (JP) | 2004-03-31 | — | — | EP | disclosed |
| CN-1118454-C | Heterocyclic derivative and medicine | NIPPON SHINYAKU CO LTD (JP) | 2003-08-20 | — | — | CN | disclosed |
| US-6191149-B1 | DRUG FOR CEREBROVASCULAR DISEASE | NIPPON SHINYAKU, CO., LTD. (JP) | 2001-02-20 | — | — | US | disclosed |
| US-5945426-A | PREVENT NEURONAL DEATH | NIPPON SHINYAKU CO., LTD. (JP) | 1999-08-31 | — | — | US | disclosed |
| EP-0781766-A1 | HETEROCYCLIC DERIVATIVE AND MEDICINE | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1997-07-02 | — | — | EP | disclosed |