Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.59 |
| ▸ | LTA4H | P09960 | 1/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.55 |
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | RXRB | P28702 | 1/20 | 0.51 |
| ▸ | RXRG | P48443 | 1/20 | 0.51 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7462666 | 0.89 | LTA4H (0.51) | BRD4LTA4HMAPK14ADRA1ASGMS2 | |
| SCHEMBL26013299 | 0.84 | MAPT (0.63) | BRD4LTA4HMAPK14SGMS2IDO1 | |
| SCHEMBL8210963 | 0.82 | BRD4 (0.53) | BRD4LTA4HMAPK14ADRA1ASGMS2 | |
| SCHEMBL28284772 | 0.82 | ADRA1D (0.58) | BRD4LTA4HMAPK14ADRA1ASGMS2 | |
| SCHEMBL9566443 | 0.80 | BRD4 (0.57) | BRD4LTA4HMAPK14SGMS2PDE5A | |
| SCHEMBL1423699 | 0.79 | CYP11B1 (0.60) | BRD4LTA4HMAPK14ADRA1ASGMS2 | |
| SCHEMBL201074 | 0.79 | RXRA (0.70) | BRD4ADRA1AIDO1MAPTMAPK1 | |
| SCHEMBL16416752 | 0.78 | LTA4H (0.64) | LTA4HMAPK14SGMS2PDE5APDE4A | |
| SCHEMBL339812 | 0.77 | MAPT (0.71) | BRD4LTA4HMAPK14ADRA1AIDO1 | |
| SCHEMBL28185277 | 0.77 | PDE5A (0.53) | ADRA1APDE5AMAPTTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817773-B1 | PYRIMIDINE COMPOUNDS | QINETIQ LTD (GB) | 2002-06-12 | — | — | EP | disclosed |
| US-6121448-A | LIQUID CRYSTALLINE COMPOUNDS | THE SECRETARY OF STATE FOR DEFENCE IN HER BRITTANIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND (GB) | 2000-09-19 | — | — | US | disclosed |
| US-5986096-A | REACTION OF HYDROGEN IODIDE WITH CHLORO-5-BROMOPYRIMIDINE | THE SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S A GOVERNMENT OF THE U.K. OF GT. BRITAIN & N. IRELAND OF DEFENCE EVALUATION & RESEARCH AGENCY (GB) | 1999-11-16 | — | — | US | disclosed |
| WO-1996030344-A9 | PYRIMIDINE COMPOUNDS | — | 1999-02-11 | — | — | WO | disclosed |
| WO-1996030344-A2 | PYRIMIDINE COMPOUNDS | THE SECRETARY OF STATE FOR DEFENCE (GB) | 1996-10-03 | — | — | WO | disclosed |