Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 6/20 | 0.57 |
| ▸ | RARB | P10826 | 6/20 | 0.57 |
| ▸ | RARG | P13631 | 6/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.35 |
| ▸ | EIF4H | Q15056 | 2/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6591838 | 0.94 | RARA (0.56) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL6588111 | 0.89 | RARA (0.48) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL6590791 | 0.88 | RARA (0.53) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL6596743 | 0.84 | CYP3A4 (0.49) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL6588514 | 0.83 | RARA (0.45) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL1140748 | 0.83 | RARA (0.48) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL6590257 | 0.82 | RARA (0.43) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL6594047 | 0.81 | RARA (0.42) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL6592559 | 0.80 | RARA (0.46) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL6596136 | 0.80 | RARB (0.46) | RARARARBRARGCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042313-B1 | BENZOPYRAN AND BENZOTHIOPYRAN DERIVATIVES HAVING RETINOID ANTAGONIST LIKE ACTIVITY | ALLERGAN INC (US) | 2004-04-28 | — | — | EP | disclosed |
| EP-1042313-A1 | BENZOPYRAN AND BENZOTHIOPYRAN DERIVATIVES HAVING RETINOID ANTAGONIST LIKE ACTIVITY | Allergan Sales, Inc. (US) | 2000-10-11 | — | — | EP | disclosed |
| US-5958954-A | 2,2-DIALKYL-4-ARYL-SUBSTITUTED BENZOPYRAN AND BENZOTHIOPYRAN DERIVATIVES | ALLERGAN SALES, INC. (US) | 1999-09-28 | — | — | US | disclosed |
| WO-1999033821-A1 | BENZOPYRAN AND BENZOTHIOPYRAN DERIVATIVES HAVING RETINOID ANTAGONIST-LIKE ACTIVITY | ALLERGAN SALES, INC. (US) | 1999-07-08 | — | — | WO | disclosed |