SCHEMBL6594367

SCHEMBL6594367

CN1CCN(c2cc(C(=O)O)nc3c(OCc4ccccc4)cccc23)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 3/20 0.47
ALDH1A1 P00352 1/20 0.46
GAA P10253 1/20 0.46
TSHR P16473 1/20 0.46
ADORA3 P0DMS8 1/20 0.44
ADORA2A P29274 1/20 0.44
ADORA1 P30542 1/20 0.44
TLR9 Q9NR96 2/20 0.44
TLR7 Q9NYK1 2/20 0.44
MAPK1 P28482 2/20 0.44
KMT2A Q03164 2/20 0.44
MEN1 O00255 1/20 0.44
HSD17B10 Q99714 1/20 0.44
LRRK2 Q5S007 2/20 0.42
AVPR2 P30518 1/20 0.42
AVPR1A P37288 1/20 0.42
MRGPRX4 Q96LA9 1/20 0.42
HTR6 P50406 2/20 0.42
HTR1A P08908 2/20 0.42
SLC6A2 P23975 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6080162 0.91 ALDH1A1 (0.46) HRH4ALDH1A1GAATSHRADORA3
SCHEMBL6594774 0.90 SMN1; SMN2 (0.46) ADORA3ADORA2AADORA1KMT2AMEN1
SCHEMBL6601817 0.89 NCF1 (0.47) ALDH1A1TSHRKMT2AMEN1USP2
SCHEMBL6593434 0.89 ALDH1A1 (0.49) HRH4ALDH1A1GAATSHRTLR9
SCHEMBL6608010 0.88 PIK3CG (0.51) ALDH1A1GAAMAPT
SCHEMBL6080078 0.82 SMN1; SMN2 (0.43) ADORA3ADORA2AADORA1KMT2AMEN1
SCHEMBL6080456 0.82 NCF1 (0.47) ALDH1A1TSHRMAPK1KMT2AMEN1
SCHEMBL6080127 0.80 ALDH1A1 (0.49) HRH4ALDH1A1GAATSHRTLR9
SCHEMBL6591671 0.79 KDM4A (0.48) ALDH1A1KMT2AMEN1HTR6USP2
SCHEMBL6080164 0.79 HRH4 (0.46) HRH4ADORA3ADORA2AADORA1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1451159-A1 COMPOSITIONS DERIVED FROM QUINOLINE AND QUINOXALINE, PREPARATION AND USE THEREOF NEURO3D (FR) 2004-09-01 EP claimed
WO-2003010146-A1 COMPOSITIONS DERIVED FROM QUINOLINE AND QUINOXALINE, PREPARATION AND USE THEREOF NEURO3D (FR) 2003-02-06 WO claimed
EP-1451159-A1 COMPOSITIONS DERIVED FROM QUINOLINE AND QUINOXALINE, PREPARATION AND USE THEREOF NEURO3D (FR) 2004-09-01 EP disclosed
WO-2003010146-A1 COMPOSITIONS DERIVED FROM QUINOLINE AND QUINOXALINE, PREPARATION AND USE THEREOF NEURO3D (FR) 2003-02-06 WO disclosed