Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 9/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6941699 | 0.86 | P2RX7 (0.70) | P2RX7GPR55MEN1USP2KMT2A | |
| SCHEMBL6941223 | 0.86 | P2RX7 (0.70) | P2RX7CA12CA9GPR55 | |
| SCHEMBL6939890 | 0.84 | P2RX7 (0.70) | P2RX7CA12CA9GPR55MEN1 | |
| SCHEMBL6939404 | 0.84 | P2RX7 (0.72) | P2RX7GPR55 | |
| SCHEMBL6939213 | 0.81 | P2RX7 (0.59) | P2RX7CA12CA9GPR55 | |
| SCHEMBL12932448 | 0.81 | P2RX7 (0.75) | P2RX7CA12CA9GPR55MEN1 | |
| SCHEMBL6941695 | 0.78 | P2RX7 (0.65) | P2RX7CA12CA9GPR55MEN1 | |
| SCHEMBL4357793 | 0.76 | EPHX2 (0.70) | MEN1KMT2A | |
| SCHEMBL6940565 | 0.76 | P2RX7 (1.00) | P2RX7MEN1USP2KMT2A | |
| SCHEMBL6940510 | 0.76 | P2RX7 (0.72) | P2RX7CA12CA9GPR55MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230227-B1 | BENZOXA-AND BENZOTHIAZOLYL SULFAMATES AND THEIR USE AS STEROID SULFATASE INHIBITORS | NOVARTIS AG (CH) | 2004-06-23 | — | — | EP | disclosed |
| US-6716865-B1 | SUBSTITUTED AT THE 2 POSITION; A SULFAMATE BOUND VIA OXYGEN TO THE PHENYL PART OF THE RING STRUCTURE; SULFAMOYLATION; STEROID SULFATASE INHIBITOR, ACNE | NOVARTIS AG (CH) | 2004-04-06 | — | — | US | disclosed |
| EP-1230227-A1 | BENZOXA-AND BENZOTHIAZOLYL SULFAMATES AND THEIR USE AS STEROID SULFATASE INHIBITORS | Novartis AG (CH) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001036398-A1 | BENZOXA- AND BENZTHIAZOLES | NOVARTIS AG (CH) | 2001-05-25 | — | — | WO | disclosed |