Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 11/20 | 0.70 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939890 | 0.90 | P2RX7 (0.70) | P2RX7GPR55MEN1USP2KMT2A | |
| SCHEMBL6594387 | 0.86 | P2RX7 (0.61) | P2RX7GPR55MEN1USP2KMT2A | |
| SCHEMBL6941223 | 0.84 | P2RX7 (0.70) | P2RX7GPR55 | |
| SCHEMBL6940565 | 0.82 | P2RX7 (1.00) | P2RX7MEN1USP2KMT2A | |
| SCHEMBL6939404 | 0.82 | P2RX7 (0.72) | P2RX7GPR55 | |
| SCHEMBL12932448 | 0.79 | P2RX7 (0.75) | P2RX7GPR55MEN1USP2KMT2A | |
| SCHEMBL6567675 | 0.78 | P2RX7 (0.65) | P2RX7GPR55MEN1USP2KMT2A | |
| SCHEMBL3321984 | 0.77 | P2RX7 (0.72) | P2RX7GPR55MEN1USP2KMT2A | |
| SCHEMBL6941695 | 0.76 | P2RX7 (0.65) | P2RX7GPR55MEN1USP2KMT2A | |
| SCHEMBL6941644 | 0.75 | P2RX7 (1.00) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | claimed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | claimed |
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | disclosed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | disclosed |
| EP-1036058-A1 | ADAMANTANE DERIVATIVES | AstraZeneca UK Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029660-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |