Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.70 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939404 | 0.90 | P2RX7 (0.72) | P2RX7GPR55ABCB11 | |
| SCHEMBL6594387 | 0.86 | P2RX7 (0.61) | P2RX7GPR55CA12CA9 | |
| SCHEMBL6941699 | 0.84 | P2RX7 (0.70) | P2RX7GPR55 | |
| SCHEMBL6939157 | 0.84 | P2RX7 (0.82) | P2RX7 | |
| SCHEMBL6939826 | 0.83 | P2RX7 (0.68) | P2RX7GPR55ABCB11 | |
| SCHEMBL18992830 | 0.82 | P2RX7 (0.62) | P2RX7 | |
| SCHEMBL12932448 | 0.82 | P2RX7 (0.75) | P2RX7GPR55CA12CA9EPHX2 | |
| SCHEMBL6939890 | 0.82 | P2RX7 (0.70) | P2RX7GPR55CA12CA9 | |
| SCHEMBL6939213 | 0.79 | P2RX7 (0.59) | P2RX7GPR55CA12CA9 | |
| SCHEMBL7660416 | 0.78 | P2RX7 (0.58) | P2RX7GPR55ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | claimed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | claimed |
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | disclosed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | disclosed |
| EP-1036058-A1 | ADAMANTANE DERIVATIVES | AstraZeneca UK Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029660-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |