SCHEMBL6594485

SCHEMBL6594485

CC(C)(C)OC(=O)CC(=O)OC(C)(C)C.COc1cc(C(C(=O)O)C(=O)O)cc(F)c1[N+](=O)[O-]

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 4/20 0.39
MTNR1B P49286 4/20 0.39
PKM P14618 1/20 0.35
HTT P42858 1/20 0.34
CYP2C19 P33261 2/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
ALDH1A1 P00352 2/20 0.33
AKR1C3 P42330 2/20 0.33
AKR1C2 P52895 2/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
CCNT1 O60563 1/20 0.33
CDK9 P50750 1/20 0.33
GRM8 O00222 1/20 0.32
GRM4 Q14833 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7534714 0.85 CYP19A1 (0.40) HTTALDH1A1MAPTLMNA
SCHEMBL2431866 0.84 PKM (0.36) MTNR1AMTNR1BPKMHTTCYP2C19
SCHEMBL4612027 0.74 AKR1C3 (0.39) PKMHTTALDH1A1AKR1C3AKR1C2
SCHEMBL7430770 0.72 CYP19A1 (0.42) HTTALDH1A1MAPTLMNA
SCHEMBL14592011 0.71 PKM (0.38) PKMHTTCYP3A4ALDH1A1AKR1C3
SCHEMBL1151448 0.68 MTNR1A (0.43) MTNR1AMTNR1BHTTALDH1A1MAPT
SCHEMBL2434981 0.68 ITGA4 (0.39) HTTALDH1A1MAPTLMNA
SCHEMBL18562555 0.68 PKM (0.39) PKMHTTCYP2C19ALDH1A1MAPT
SCHEMBL30087222 0.68 HTT (0.53) PKMHTTALDH1A1MAPTHPGD
SCHEMBL1675837 0.68 HTT (0.53) PKMHTTALDH1A1MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144393-B1 BENZOXAZOLE DERIVATIVES FOR USE AS INTEGRIN INHIBITORS ASTRAZENECA AB (SE) 2004-02-11 EP disclosed
EP-1144393-A3 HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITOR AstraZeneca AB (SE) 2002-09-11 EP disclosed
US-6441012-B1 BENZOXAZOLE OR BENZTHIAZOLE DERIVATIVES FOR INHIBITING THE INTERACTION BETWEEN CELLULAR ADHESION MOLECULES AND/OR FIBRONECTIN AND THE INTERGRIN RECEPTOR ASTRAZENECA AB (SE) 2002-08-27 US disclosed
EP-1144393-A2 HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITOR AstraZeneca AB (SE) 2001-10-17 EP disclosed
EP-1133484-A2 HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS AstraZeneca AB (SE) 2001-09-19 EP disclosed
WO-2000005223-A2 HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS ASTRAZENECA AB (SE) 2000-02-03 WO disclosed
WO-2000005224-A2 HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITOR ASTRAZENECA AB (SE) 2000-02-03 WO disclosed