Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 5/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | NCF1 | P14598 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30058924 | 0.84 | ADRB2 (1.00) | ADRB2MAPK1MAPTADRA2AHTR2C | |
| SCHEMBL6125222 | 0.84 | ADRB2 (0.72) | ADRB2MAPK1MAPTADRA2AHTR2C | |
| SCHEMBL2711296 | 0.84 | ADRB2 (1.00) | ADRB2MAPK1MAPTADRA2AHTR2C | |
| SCHEMBL23362148 | 0.82 | ADRB2 (0.68) | ADRB2MAPK1MAPTADRA2AHTR2C | |
| SCHEMBL30058841 | 0.82 | ADRB2 (0.68) | ADRB2MAPK1MAPTADRA2AHTR2C | |
| SCHEMBL23362808 | 0.81 | MAPK1 (0.82) | ADRB2MAPK1MAPTADRA2AHTR2C | |
| SCHEMBL2724231 | 0.80 | ADRB2 (0.90) | ADRB2MAPK1MAPTADRA2AHTR2C | |
| SCHEMBL895026 | 0.79 | ADRB2 (0.64) | ADRB2MAPK1MAPTADRA2AHTR2C | |
| SCHEMBL3863739 | 0.79 | NCF1 (0.70) | ADRB2MAPK1MAPTADRA2AHTR2C | |
| SCHEMBL5310874 | 0.78 | MAPK1 (0.69) | ADRB2MAPK1MAPTADRA2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069124-B1 | 2-Benzimidazolylamine compounds as ORL1-receptor agonists | PFIZER (US) | 2004-05-12 | — | — | EP | disclosed |