Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6594949 | 0.93 | HDAC6 (0.50) | P2RY14MEN1KMT2AUSP2HDAC6 | |
| SCHEMBL6598330 | 0.92 | P2RY14 (0.49) | P2RY14MEN1KMT2AUSP2HDAC6 | |
| SCHEMBL6593054 | 0.85 | HDAC6 (0.40) | HDAC6 | |
| SCHEMBL6594493 | 0.85 | HDAC6 (0.52) | P2RY14MEN1KMT2AHDAC6 | |
| SCHEMBL3866405 | 0.84 | RAB9A (0.45) | P2RY14HDAC6ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7657273 | 0.84 | EPHX2 (0.49) | P2RY14MEN1KMT2AUSP2HDAC6 | |
| SCHEMBL7427423 | 0.83 | P2RY14 (0.43) | P2RY14MEN1KMT2AUSP2HDAC6 | |
| SCHEMBL6597368 | 0.81 | NPC1 (0.47) | USP2HDAC6ALDH1A1 | |
| SCHEMBL2438782 | 0.80 | NPC1 (0.51) | MEN1KMT2AUSP2HDAC6ALDH1A1 | |
| SCHEMBL6596100 | 0.80 | USP2 (0.46) | P2RY14MEN1KMT2AUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144393-B1 | BENZOXAZOLE DERIVATIVES FOR USE AS INTEGRIN INHIBITORS | ASTRAZENECA AB (SE) | 2004-02-11 | — | — | EP | disclosed |
| EP-1144393-A3 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITOR | AstraZeneca AB (SE) | 2002-09-11 | — | — | EP | disclosed |
| US-6441012-B1 | BENZOXAZOLE OR BENZTHIAZOLE DERIVATIVES FOR INHIBITING THE INTERACTION BETWEEN CELLULAR ADHESION MOLECULES AND/OR FIBRONECTIN AND THE INTERGRIN RECEPTOR | ASTRAZENECA AB (SE) | 2002-08-27 | — | — | US | disclosed |
| EP-1144393-A2 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITOR | AstraZeneca AB (SE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000005224-A2 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITOR | ASTRAZENECA AB (SE) | 2000-02-03 | — | — | WO | disclosed |