Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.49 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598330 | 0.92 | P2RY14 (0.49) | EPHX2P2RY14USP2HDAC6ITGA4 | |
| SCHEMBL7668355 | 0.85 | HDAC6 (0.42) | EPHX2KDM4EALDH1A1HDAC6KMT2A | |
| SCHEMBL6594493 | 0.85 | HDAC6 (0.52) | EPHX2P2RY14HDAC6MEN1KMT2A | |
| SCHEMBL6595168 | 0.84 | P2RY14 (0.49) | P2RY14USP2ALDH1A1HDAC6MEN1 | |
| SCHEMBL3866405 | 0.84 | RAB9A (0.45) | P2RY14ALDH1A1HDAC6ITGA4 | |
| SCHEMBL7430484 | 0.82 | EPHX2 (0.47) | EPHX2KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL6597368 | 0.81 | NPC1 (0.47) | KDM4EUSP2ALDH1A1POLBHPGD | |
| SCHEMBL7659834 | 0.80 | KDM4E (0.52) | KDM4EUSP2ALDH1A1ESR1POLB | |
| SCHEMBL7668364 | 0.80 | HDAC6 (0.38) | EPHX2ALDH1A1HDAC6ITGA4TSHR | |
| SCHEMBL6165048 | 0.78 | ALDH1A1 (0.41) | KDM4EUSP2ALDH1A1ESR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144393-A3 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITOR | AstraZeneca AB (SE) | 2002-09-11 | — | — | EP | disclosed |
| US-6441012-B1 | BENZOXAZOLE OR BENZTHIAZOLE DERIVATIVES FOR INHIBITING THE INTERACTION BETWEEN CELLULAR ADHESION MOLECULES AND/OR FIBRONECTIN AND THE INTERGRIN RECEPTOR | ASTRAZENECA AB (SE) | 2002-08-27 | — | — | US | disclosed |
| EP-1144393-A2 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITOR | AstraZeneca AB (SE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000005224-A2 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITOR | ASTRAZENECA AB (SE) | 2000-02-03 | — | — | WO | disclosed |