Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASH1L | Q9NR48 | 4/20 | 0.52 |
| ▸ | CDK4 | P11802 | 3/20 | 0.42 |
| ▸ | CCND1 | P24385 | 3/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27613441 | 0.81 | ASH1L (0.60) | ASH1LCDK4CCND1BACE1MAPT | |
| SCHEMBL3675588 | 0.74 | ASH1L (0.74) | ASH1LAXLTDO2GSK3B | |
| SCHEMBL5733465 | 0.73 | SUCNR1 (0.51) | MAPTHTTLMNAPOLBMEN1 | |
| Propionic Acid SCHEMBL19133622 | 0.72 | IMPDH2 (0.56) | ASH1LAXLMAPTPOLBMEN1 | |
| SCHEMBL5734842 | 0.72 | POLB (0.73) | MAPTHTTLMNAPOLBMEN1 | |
| SCHEMBL22044083 | 0.72 | BACE1 (0.71) | ASH1LCDK4CCND1AXLBACE1 | |
| SCHEMBL5734472 | 0.72 | LMNA (0.55) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL5732711 | 0.71 | POLB (0.50) | MAPTLMNAPOLBMEN1NPC1 | |
| SCHEMBL2003500 | 0.70 | SLC22A6 (0.55) | ASH1LCDK4CCND1BACE1MAPT | |
| SCHEMBL2300936 | 0.70 | ASH1L (0.52) | ASH1LCDK4CCND1TDO2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409455-A1 | PROSTAGLANDIN ANALOGUES-AS EP4 RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003008377-A1 | PROSTAGLANDIN ANALOGUES_AS EP4 RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-01-30 | — | — | WO | disclosed |