Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASH1L | Q9NR48 | 2/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 8/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370732 | 0.81 | ASH1L (0.55) | ASH1LTDO2NR4A2IMPDH2MAPK1 | |
| SCHEMBL31370363 | 0.80 | KMT2A (0.59) | ASH1LMAPK1HSD17B10 | |
| SCHEMBL27613441 | 0.77 | ASH1L (0.60) | ASH1LTDO2NR4A2IMPDH2MAPK1 | |
| SCHEMBL7807902 | 0.76 | BRD4 (0.54) | ASH1L | |
| SCHEMBL2003500 | 0.76 | SLC22A6 (0.55) | ASH1LPBRM1GSK3BTDO2NR4A2 | |
| SCHEMBL21997278 | 0.75 | GRIA2 (0.50) | — | |
| SCHEMBL3675588 | 0.74 | ASH1L (0.74) | ASH1LGSK3BTDO2NR4A2IMPDH2 | |
| SCHEMBL15214656 | 0.74 | BCL2 (0.53) | NR4A2 | |
| Propionic Acid SCHEMBL19133578 | 0.73 | PRKCB (0.47) | ASH1LNR4A2 | |
| SCHEMBL25043136 | 0.73 | ASH1L (0.59) | ASH1LTDO2NR4A2IMPDH2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |