SCHEMBL659537

SCHEMBL659537

CCCCNc1ccccc1N

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 4/20 0.54
HDAC6 Q9UBN7 2/20 0.45
CYP1A2 P05177 3/20 0.44
CYP2C9 P11712 3/20 0.44
CYP2C19 P33261 3/20 0.44
CYP3A4 P08684 1/20 0.44
HDAC3 O15379 3/20 0.42
HDAC1 Q13547 3/20 0.42
HDAC2 Q92769 3/20 0.42
MAPT P10636 3/20 0.42
NCOR2 Q9Y618 2/20 0.42
HTT P42858 1/20 0.42
UTS2R Q9UKP6 1/20 0.42
KDM4E B2RXH2 3/20 0.41
ALDH1A1 P00352 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
NPSR1 Q6W5P4 1/20 0.41
APAF1 O14727 1/20 0.41
GAA P10253 2/20 0.41
MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29636805 1.00 TLR8 (0.54) TLR8HDAC6CYP1A2CYP2C9CYP2C19
SCHEMBL1170549 0.94 TLR8 (0.49) TLR8HDAC6CYP1A2CYP2C9CYP2C19
SCHEMBL29922455 0.94 TLR8 (0.49) TLR8HDAC6CYP1A2CYP2C9CYP2C19
SCHEMBL8088625 0.92 L3MBTL1 (0.48) TLR8HDAC6CYP1A2CYP2C9CYP2C19
SCHEMBL7970465 0.92 L3MBTL1 (0.48) TLR8HDAC6CYP1A2CYP2C9CYP2C19
SCHEMBL9168077 0.92 L3MBTL1 (0.48) TLR8HDAC6CYP1A2CYP2C9CYP2C19
SCHEMBL7365605 0.92 L3MBTL1 (0.48) TLR8HDAC6CYP1A2CYP2C9CYP2C19
SCHEMBL9011310 0.92 L3MBTL1 (0.48) TLR8HDAC6CYP1A2CYP2C9CYP2C19
SCHEMBL21799596 0.92 L3MBTL1 (0.48) TLR8HDAC6CYP1A2CYP2C9CYP2C19
SCHEMBL8082845 0.92 L3MBTL1 (0.48) TLR8HDAC6CYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110650944-A Silica-based zinc catalysts, their preparation and use in the alkoxycarbonylation of amines 科思创德国股份有限公司 2020-01-03 CN claimed
CN-108048142-A A kind of military typed high-energy liquid fuel in alcohol group and preparation method thereof 山东联星能源集团有限公司 2018-05-18 CN claimed
CN-104788774-A Formula for special protective film of brushed aluminum plate KUNSHAN JINHUAAN ELECTRONIC TECHNOLOGY CO LTD 2015-07-22 CN claimed
CN-104788805-A Special PP protecting membrane formula for ITO KUNSHAN JINHUAAN ELECTRONIC TECHNOLOGY CO LTD 2015-07-22 CN claimed
EP-3623398-B1 RESIN COMPOSITION COMPRISING A MODIFIED BLOCK COPOLYMER AND METHOD FOR PRODUCING MODIFIED BLOCK COPOLYMER ASAHI CHEMICAL IND (JP) 2024-08-28 EP disclosed
CN-118159831-A Fluorescent imaging agent for lipid droplets in cells and tissues 国立大学法人群马大学 2024-06-07 CN disclosed
WO-2023192843-A1 ANTIFOULANT COMPOSITIONS FOR HIGH-SEVERITY PROCESSING OF VINYLIC MONOMER STREAMS ECOLAB USA INC. (US) 2023-10-05 WO disclosed
US-20230288395-A1 OXIDATIVE STABILITY TEST METHODS FOR CHEMICALLY RECYCLED PLASTIC FEEDSTOCKS ECOLAB USA INC. (US) 2023-09-14 US disclosed
US-20230257380-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2023-08-17 US disclosed
US-20230183453-A1 SILANE FUNCTIONAL AMINE COMPOSITIONS AND THEIR USE IN RUBBER MOMENTIVE PERFORMANCE MATERIALS INC. 2023-06-15 US disclosed
CN-110603273-B Modified block copolymer, method for producing modified block copolymer, and resin composition 旭化成株式会社 2022-10-14 CN disclosed
CN-109153915-B Polymerizable liquid crystal material and polymerized liquid crystal film 默克专利股份有限公司 2022-09-23 CN disclosed
EP-0431756-A2 Polyol and rigid polyurethane foam MITSUI TOATSU CHEMICALS, Inc. (JP) 1991-06-12 EP disclosed
EP-0119428-A2 Biscarboxamides for treating diseases, and process for their preparation BAYER AG (DE) 1984-09-26 EP disclosed
EP-0000742-B1 CORTICOIDS-17-ALKYLCARBONATES, PROCESS FOR THEIR PREPARATION AND PREPARATIONS CONTAINING THEM HOECHST AKTIENGESELLSCHAFT (DE) 1982-05-12 EP disclosed
US-4311700-A ANTIULCER, GASTROINTESTINAL DISORDERS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1982-01-19 US disclosed
EP-0024582-A1 Benzodiazepinones, process for their preparation and pharmaceutical compositions containing them Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1981-03-11 EP disclosed
WO-1981000568-A1 BENZODIAZEPINONES,A PROCESS FOR THEIR PREPARATION,THEIR USE AND MEDICAMENTS CONTAINING THEM BYK GULDEN LOMBERG CHEM FAB (DE) 1981-03-05 WO disclosed
US-3950391-A FUNGICIDES, MITICIDES, OVICIDES ADAMS CHARLES D 1976-04-13 US disclosed
US-3931215-A OPTICAL BRIGHTENERS HOECHST AKTIENGESELLSCHAFT (DT) 1976-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230257380-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE MUSK, ERBB2, NTRK1 TLR8 4008/4885HDAC6 606/4885CYP1A2 4437/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.