Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6595615 | 1.00 | HPGD (0.57) | HPGDHDAC4HDAC8GPR119AKR1B1 | |
| SCHEMBL29029524 | 0.88 | PIM1 (0.58) | HPGDGPR119FAAH | |
| SCHEMBL29029526 | 0.88 | PIM1 (0.58) | HPGDGPR119FAAH | |
| SCHEMBL6598068 | 0.85 | GPR119 (0.56) | HPGDGPR119MAOAMAOB | |
| SCHEMBL6598426 | 0.85 | GPR119 (0.56) | HPGDGPR119MAOAMAOB | |
| SCHEMBL6596314 | 0.84 | HPGD (0.60) | HPGDGPR119AKR1B1 | |
| SCHEMBL6596488 | 0.84 | HPGD (0.60) | HPGDGPR119AKR1B1 | |
| SCHEMBL30864157 | 0.82 | HPGD (0.66) | HPGDGPR119AKR1B1 | |
| SCHEMBL30440951 | 0.82 | HPGD (0.66) | HPGDGPR119AKR1B1 | |
| SCHEMBL6596168 | 0.82 | FAAH (0.58) | FAAHNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0981526-B1 | NOVEL ANTIDIABETIC COMPOUNDS HAVING HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | REDDYS LAB LTD DR (IN) | 2004-02-25 | — | — | EP | claimed |
| EP-0981526-B1 | NOVEL ANTIDIABETIC COMPOUNDS HAVING HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | REDDYS LAB LTD DR (IN) | 2004-02-25 | — | — | EP | disclosed |