SCHEMBL6596229

SCHEMBL6596229

COc1c(C(=O)Cl)sc2ccccc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.51
MAPK1 P28482 1/20 0.51
MAPT P10636 4/20 0.50
KMT2A Q03164 4/20 0.50
ALDH1A1 P00352 3/20 0.50
GAA P10253 2/20 0.50
ATM Q13315 2/20 0.50
HPGD P15428 2/20 0.50
KDM4E B2RXH2 1/20 0.50
MEN1 O00255 1/20 0.50
GLA P06280 1/20 0.50
ALOX15 P16050 1/20 0.50
HSD17B10 Q99714 1/20 0.50
MAOB P27338 1/20 0.49
ALOX5 P09917 1/20 0.48
MCL1 Q07820 1/20 0.47
F10 P00742 1/20 0.46
SENP5 Q96HI0 1/20 0.46
SENP2 Q9HC62 1/20 0.46
SENP1 Q9P0U3 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1098130 0.85 MCL1 (0.57) LMNAMAPK1MAPTKMT2AALDH1A1
SCHEMBL9603073 0.85 MAPT (0.59) LMNAMAPK1MAPTKMT2AALDH1A1
SCHEMBL9025214 0.83 LMNA (0.69) LMNAMAPK1MAPTKMT2AALDH1A1
SCHEMBL5453335 0.83 LIMK1 (0.60) LMNAMAPK1MAPTKMT2AALDH1A1
SCHEMBL11085667 0.81 LMNA (0.43) LMNAMAPK1MAPTKMT2AALDH1A1
SCHEMBL29445497 0.81 HDAC1 (0.60) LMNAMAPK1MAPTKMT2AALDH1A1
SCHEMBL11798884 0.80 ABCB11 (0.47) LMNAMAPK1MAPTALDH1A1GAA
SCHEMBL2610245 0.77 RXFP1 (0.59) LMNAMAPK1MAPTKMT2AALDH1A1
SCHEMBL9024182 0.77 SENP5 (0.58) LMNAMAPK1MAPTKMT2AALDH1A1
SCHEMBL10747184 0.77 LMNA (0.46) LMNAMAPK1MAPTKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1040108-B1 ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS SCHERING AG (DE) 2004-02-25 EP disclosed
US-6498185-B1 ENZYME FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. 2002-12-24 US disclosed
US-6380221-B1 FOR THERAPY OF DISEASE-STATES CHARACTERIZED BY THROMBOTIC ACTIVITY BERLEX LABORATORIES, INC. 2002-04-30 US disclosed
US-6140351-A FOR TREATING THROMBOSIS BERLEX LABORATORIES, INC. (US) 2000-10-31 US disclosed
EP-1040108-A1 ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS SCHERING AKTIENGESELLSCHAFT (DE) 2000-10-04 EP disclosed
WO-1999032477-A1 ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS SCHERING AKTIENGESELLSCHAFT (DE) 1999-07-01 WO disclosed
US-4663344-A ANTIPYRETICS, ANTIARTHRITIC AGENTS MERCK & CO., INC. (US) 1987-05-05 US disclosed
US-3976780-A Methods of protection against emesis in mammals by administration of a 3-alkoxy-thianaphthene-2-carboxamide SOCIETE D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES L'ILE-DE-FRANCE (FR) 1976-08-24 US disclosed
US-3954748-A ANTIEMETICS SOCIETE D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE-DE-FRANCE (FR) 1976-05-04 US disclosed