SCHEMBL6596963

SCHEMBL6596963

O=C(O)C=C1C2CC3CC(C2)CC1C3

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 1.00
ESR1 P03372 1/20 0.35
THRB P10828 1/20 0.34
CYP2C9 P11712 1/20 0.34
KDM4E B2RXH2 1/20 0.33
NPC1 O15118 1/20 0.33
ITGB3 P05106 1/20 0.32
ITGB1 P05556 1/20 0.32
ITGAV P06756 1/20 0.32
ITGA4 P13612 1/20 0.32
HSD11B1 P28845 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15004473 0.79 TSHR (0.65) TSHRITGB3ITGB1ITGAVITGA4
SCHEMBL2090407 0.76 TSHR (0.60) TSHR
SCHEMBL15004474 0.74 TSHR (0.59) TSHRITGB3ITGB1ITGAVITGA4
SCHEMBL2749102 0.74 TSHR (0.59) TSHRESR1KDM4ENPC1
Adamantane SCHEMBL2307508 0.68 THRB (0.61) TSHRESR1THRBCYP2C9NPC1
Adamantane SCHEMBL2307499 0.68 THRB (0.61) TSHRESR1THRBCYP2C9NPC1
SCHEMBL7401851 0.67 TSHR (0.50) TSHRESR1KDM4ENPC1HSD11B1
Adamantane SCHEMBL935449 0.66 HSD11B1 (0.48) TSHRTHRBCYP2C9HSD11B1
Adamantane SCHEMBL974954 0.66 HSD11B1 (0.48) TSHRTHRBCYP2C9HSD11B1
Adamantane SCHEMBL3981833 0.66 HSD11B1 (0.48) TSHRTHRBCYP2C9HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1230227-B1 BENZOXA-AND BENZOTHIAZOLYL SULFAMATES AND THEIR USE AS STEROID SULFATASE INHIBITORS NOVARTIS AG (CH) 2004-06-23 EP disclosed
US-6716865-B1 SUBSTITUTED AT THE 2 POSITION; A SULFAMATE BOUND VIA OXYGEN TO THE PHENYL PART OF THE RING STRUCTURE; SULFAMOYLATION; STEROID SULFATASE INHIBITOR, ACNE NOVARTIS AG (CH) 2004-04-06 US disclosed
EP-1230227-A1 BENZOXA-AND BENZOTHIAZOLYL SULFAMATES AND THEIR USE AS STEROID SULFATASE INHIBITORS Novartis AG (CH) 2002-08-14 EP disclosed
WO-2001036398-A1 BENZOXA- AND BENZTHIAZOLES NOVARTIS AG (CH) 2001-05-25 WO disclosed
EP-0246114-B1 PHOTOCHROMIC SPIROPYRAN COMPOUNDS GEC-MARCONI LIMITED (GB) 1992-09-02 EP disclosed
US-4826977-A Photochromic spiropyran compounds THE PLESSEY COMPANY PLC (GB) 1989-05-02 US disclosed
EP-0246114-A2 Photochromic spiropyran compounds GEC-MARCONI LIMITED (GB) 1987-11-19 EP disclosed