Adamantane

Adamantane

SCHEMBL2307499

C1C2CC3CC1CC(C2)C3.O=C(O)/C=C/C(=O)O

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol

The experimentally established mechanism targets of Adamantane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.61
CYP2C9 P11712 1/20 0.61
TSHR P16473 3/20 0.60
TP53 P04637 1/20 0.60
EGLN1 Q9GZT9 1/20 0.60
EGLN3 Q9H6Z9 1/20 0.60
POLB P06746 1/20 0.44
ATM Q13315 1/20 0.42
HSD11B1 P28845 1/20 0.40
HTT P42858 1/20 0.39
NPC1 O15118 1/20 0.39
GAA P10253 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
HCAR2 Q8TDS4 1/20 0.39
ESR1 P03372 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Adamantane SCHEMBL2307508 1.00 THRB (0.61) THRBCYP2C9TSHRTP53EGLN1
Fumaric Acid SCHEMBL28755166 0.88 THRB (0.56) THRBCYP2C9TSHRTP53EGLN1
Adamantane SCHEMBL4451200 0.87 THRB (0.50) THRBCYP2C9TSHRTP53EGLN1
Adamantane SCHEMBL4451206 0.87 THRB (0.50) THRBCYP2C9TSHRTP53EGLN1
Adamantane SCHEMBL6817495 0.85 THRB (0.48) THRBCYP2C9TSHRTP53EGLN1
Adamantane SCHEMBL3981833 0.78 HSD11B1 (0.48) THRBCYP2C9TSHRHSD11B1
Adamantane SCHEMBL974954 0.78 HSD11B1 (0.48) THRBCYP2C9TSHRHSD11B1
Adamantane SCHEMBL935449 0.78 HSD11B1 (0.48) THRBCYP2C9TSHRHSD11B1
Fumaric Acid SCHEMBL2046433 0.78 TSHR (1.00) THRBCYP2C9TSHRTP53EGLN1
Fumaric Acid SCHEMBL615 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2350386-A1 METHOD FOR MANUFACTURING SHEET MATERIAL Filsen Pty Ltd (AU) 2011-08-03 EP disclosed
US-20100272920-A1 Radiation Curable System Garnett, John Lyndon (AU) 2010-10-28 US disclosed
WO-2009043110-A1 METHOD FOR MANUFACTURING SHEET MATERIAL FILSEN PTY LTD (AU) 2009-04-09 WO disclosed
EP-1278781-A4 RADIATION POLYMERISABLE COMPOSITIONS BALLINA PTY LTD (AU) 2005-01-26 EP disclosed
US-6767933-B2 CONTAINING CHARGE TRANSFER COMPOUND BALLINA PTY LTD (AU) 2004-07-27 US disclosed
US-20040044094-A1 Radiation polymerisable compositions having accelerated cure GARNETT JOHN LYNDON (AU) 2004-03-04 US disclosed
EP-1332187-A1 RADIATION POLYMERISABLE COMPOSITIONS HAVING ACCELERATED CURE Garnett, John Lyndon (AU) 2003-08-06 EP disclosed
US-20030073755-A1 Radiation polymerisable compositions BALLINA PTY. LTD. (AU) 2003-04-17 US disclosed
WO-2003018642-A1 PREPARATION OF POLYMER COMPOSITES GARNETT JOHN LYNDON (AU) 2003-03-06 WO disclosed
EP-1278781-A1 RADIATION POLYMERISABLE COMPOSITIONS Ballina Pty. Ltd. (AU) 2003-01-29 EP disclosed
WO-2002020677-A1 RADIATION POLYMERISABLE COMPOSITIONS HAVING ACCELERATED CURE GARNETT JOHN LYNDON (AU) 2002-03-14 WO disclosed
WO-2001025288-A1 RADIATION POLYMERISABLE COMPOSITIONS BALLINA PTY LTD (AU) 2001-04-12 WO disclosed
EP-0618237-B1 Polymerization process FUSION UV SYS INC (US) 1998-09-02 EP disclosed
US-5446073-A Photopolymerization process employing a charge transfer complex without a photoinitiator FUSION SYSTEMS CORPORATION (US) 1995-08-29 US disclosed
EP-0618237-A1 Polymerization process FUSION SYSTEMS CORPORATION (US) 1994-10-05 EP disclosed