Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6597125 | 0.83 | KDM4E (0.45) | KDM4EALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL6602000 | 0.79 | NOS1 (0.43) | KDM4EALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL6595697 | 0.74 | FLT3 (0.43) | KDM4EALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL6599982 | 0.74 | TRPA1 (0.44) | KDM4EALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL628902 | 0.74 | KDM4E (0.39) | KDM4EALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL6598902 | 0.74 | GAA (0.39) | KDM4EALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL11435579 | 0.74 | TRIM24 (0.44) | KDM4EALDH1A1NPC1RAB9ACYP3A4 | |
| SCHEMBL5375043 | 0.73 | CDK2 (0.46) | KDM4EALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL6599003 | 0.71 | MAPT (0.45) | CYP3A4CYP1A2HPGDMAPK1MEN1 | |
| SCHEMBL6610162 | 0.71 | MAPT (0.43) | GAAHPGDMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432416-A1 | AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pharmacia Italia S.p.A. (IT) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028720-A1 | AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2003-04-10 | — | — | WO | disclosed |