Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 5/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | HTR6 | P50406 | 3/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | HTR5A | P47898 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599041 | 0.84 | HTR7 (0.69) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL27588982 | 0.80 | DRD2 (0.37) | HTR7DRD2DRD4DRD3KCNH2 | |
| SCHEMBL6597396 | 0.80 | HTR7 (0.51) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL6596320 | 0.78 | HTR7 (0.69) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL7048455 | 0.78 | — | — | |
| SCHEMBL7051875 | 0.74 | DRD2 (0.56) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL7051036 | 0.70 | CYP2D6 (0.50) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL9635358 | 0.67 | — | — | |
| SCHEMBL9635334 | 0.66 | HTR7 (0.66) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL9757266 | 0.66 | HTR7 (0.81) | HTR7HTR1ADRD2HTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299384-B1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | LUNDBECK & CO AS H (DK) | 2004-03-24 | — | — | EP | claimed |
| EP-1299384-B1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | LUNDBECK & CO AS H (DK) | 2004-03-24 | — | — | EP | disclosed |
| EP-1299384-A1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. Lundbeck A/S (DK) | 2003-04-09 | — | — | EP | disclosed |
| WO-2001098298-A1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. LUNDBECK A/S (DK) | 2001-12-27 | — | — | WO | disclosed |