Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MMP7 | P09237 | 1/20 | 0.45 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31234593 | 0.84 | CA1 (0.54) | MEN1KMT2ACA1CA2ALDH1A1 | |
| SCHEMBL18680063 | 0.83 | GBA1 (0.54) | MEN1KMT2ACA1CA2ALDH1A1 | |
| SCHEMBL2934786 | 0.83 | ALDH1A1 (0.67) | GAASIGMAR1CA1CA2ALDH1A1 | |
| SCHEMBL31234771 | 0.80 | CA2 (0.53) | GAAMEN1KMT2ACA1CA2 | |
| SCHEMBL6598439 | 0.80 | MEN1 (0.48) | GAAMEN1KMT2ACA1CA2 | |
| SCHEMBL6324078 | 0.80 | SIGMAR1 (0.51) | GAASIGMAR1CA1CA2ALDH1A1 | |
| SCHEMBL3412102 | 0.80 | CA1 (0.52) | GAASIGMAR1CA1CA2ALDH1A1 | |
| SCHEMBL6321465 | 0.80 | CA1 (0.52) | GAASIGMAR1CA1CA2ALDH1A1 | |
| SCHEMBL3412348 | 0.80 | CA1 (0.52) | GAASIGMAR1CA1CA2ALDH1A1 | |
| SCHEMBL5273173 | 0.80 | CYP19A1 (0.47) | GAASIGMAR1CA1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414801-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | AstraZeneca AB (SE) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003004472-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |