Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | RXRB | P28702 | 2/20 | 0.38 |
| ▸ | RXRG | P48443 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1194595 | 0.86 | MAPT (0.38) | KMT2AALDH1A1LMNAHPGDCYP1A2 | |
| SCHEMBL6596459 | 0.80 | KMT2A (0.45) | KMT2AATMPABPC1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL1193919 | 0.79 | KMT2A (0.44) | KMT2AATMPABPC1ALDH1A1LMNA | |
| SCHEMBL5365072 | 0.73 | NPC1 (0.52) | ALDH1A1KDM4EHPGDCYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL1193715 | 0.66 | MAPT (0.34) | KMT2AALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL31055014 | 0.65 | RAB9A (0.73) | KMT2AALDH1A1LMNAKDM4ECYP1A2 | |
| Bromide SCHEMBL6225621 | 0.63 | KMT2A (0.68) | KMT2AATMPABPC1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL10416387 | 0.63 | KMT2A (0.94) | KMT2AATMPABPC1ALDH1A1LMNA | |
| SCHEMBL14445464 | 0.63 | RXRA (0.63) | NPC1RAB9ARXRARXRBRXRG | |
| SCHEMBL14445463 | 0.62 | RXRA (0.78) | RXRARXRBRXRGPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373263-B1 | HETEROCYCLIC COMPOUNDS FOR AGING-RELATED AND DIABETIC VASCULAR COMPLICATIONS | TORRENT PHARMACEUTICALS LTD (IN) | 2004-10-27 | — | — | EP | claimed |