Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28026195 | 0.78 | CYP2C19 (0.59) | CYP2C19CYP3A4CYP2D6TNFKDM4E | |
| SCHEMBL11161541 | 0.76 | CYP2C19 (0.54) | CYP2C19CYP3A4CYP2D6TNFKDM4E | |
| SCHEMBL14005999 | 0.75 | POLB (0.66) | CYP2C19CYP3A4CYP2D6TNFKDM4E | |
| SCHEMBL989290 | 0.75 | CYP2C19 (0.52) | CYP2C19CYP3A4CYP2D6TNFKDM4E | |
| SCHEMBL9597447 | 0.73 | CYP2C19 (0.59) | CYP2C19CYP3A4CYP2D6TNFKDM4E | |
| SCHEMBL1713531 | 0.73 | SMN1; SMN2 (0.55) | CYP2C19CYP3A4CYP2D6TNFKDM4E | |
| SCHEMBL2789865 | 0.72 | CYP2C19 (0.58) | CYP2C19CYP3A4CYP2D6TNFKDM4E | |
| SCHEMBL6104023 | 0.71 | ALDH1A1 (0.54) | CYP2C19CYP3A4CYP2D6TNFKDM4E | |
| SCHEMBL27942276 | 0.70 | CYP2C19 (0.48) | CYP2C19CYP3A4CYP2D6TNFKDM4E | |
| SCHEMBL9570331 | 0.70 | CYP2C19 (0.56) | CYP2C19CYP3A4CYP2D6TNFKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351958-B1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-06-16 | — | — | EP | disclosed |