Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1771402 | 0.83 | KMT2A (0.59) | TSHRALDH1A1KMT2AMEN1POLB | |
| SCHEMBL6034789 | 0.81 | SETD7 (0.59) | TSHRALDH1A1KMT2AMEN1POLB | |
| SCHEMBL6035071 | 0.81 | TSHR (0.59) | TSHRALDH1A1KMT2AMEN1POLB | |
| SCHEMBL3153541 | 0.80 | TSHR (0.58) | TSHRALDH1A1KMT2AMEN1POLB | |
| SCHEMBL3150435 | 0.78 | ALDH1A1 (0.59) | TSHRALDH1A1KMT2AMEN1POLB | |
| SCHEMBL6599669 | 0.76 | CHRNB2 (0.61) | TSHRALDH1A1KMT2AMEN1POLB | |
| SCHEMBL27506976 | 0.76 | TSHR (0.55) | TSHRALDH1A1KMT2AMEN1POLB | |
| Hydrochloric Acid SCHEMBL1763285 | 0.75 | CHRNB2 (0.60) | TSHRALDH1A1KMT2AMEN1POLB | |
| SCHEMBL2673282 | 0.75 | TSHR (0.67) | TSHRALDH1A1KMT2AMEN1POLB | |
| Ethylene SCHEMBL8379882 | 0.74 | TSHR (0.52) | TSHRALDH1A1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414801-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | AstraZeneca AB (SE) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003004472-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |