Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.61 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.61 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.61 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.61 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.57 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.57 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1763285 | 0.98 | CHRNB2 (0.60) | CHRNB2CHRNB4CHRNA3CHRNA4SCN5A | |
| SCHEMBL3153541 | 0.84 | TSHR (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4TSHR | |
| SCHEMBL3150435 | 0.81 | ALDH1A1 (0.59) | CHRNB2CHRNB4CHRNA3CHRNA4TSHR | |
| SCHEMBL6035071 | 0.81 | TSHR (0.59) | CHRNB2CHRNB4CHRNA3CHRNA4TSHR | |
| SCHEMBL27506976 | 0.80 | TSHR (0.55) | CHRNB2CHRNB4CHRNA3CHRNA4TSHR | |
| SCHEMBL1771402 | 0.80 | KMT2A (0.59) | CHRNB2CHRNB4CHRNA3CHRNA4TSHR | |
| Ethylene SCHEMBL8379882 | 0.78 | TSHR (0.52) | CHRNB2CHRNB4CHRNA3CHRNA4TSHR | |
| SCHEMBL6598093 | 0.76 | TSHR (0.54) | CHRNB2CHRNB4CHRNA3CHRNA4TSHR | |
| SCHEMBL585202 | 0.76 | CHRNA4 (1.00) | CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7 | |
| SCHEMBL6427074 | 0.75 | ALDH1A1 (0.72) | CHRNA4SCN5ASCN2ASCN10AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414801-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | AstraZeneca AB (SE) | 2004-05-06 | — | — | EP | claimed |
| WO-2003004472-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | claimed |