Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.47 |
| ▸ | CCR3 | P51677 | 9/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599332 | 0.86 | OPRM1 (0.46) | OPRM1OPRK1OPRL1CCR3SLC6A4 | |
| SCHEMBL6593968 | 0.82 | OPRM1 (0.54) | OPRM1OPRK1OPRL1SLC6A4HTR1D | |
| SCHEMBL7089113 | 0.76 | OPRM1 (0.47) | OPRM1OPRK1OPRL1SLC6A4HTR1D | |
| SCHEMBL27598011 | 0.76 | OPRM1 (0.59) | OPRM1OPRK1OPRL1SLC6A4KDM4E | |
| SCHEMBL4767736 | 0.72 | OPRM1 (0.52) | OPRM1OPRK1OPRL1SLC6A4KDM4E | |
| SCHEMBL6595114 | 0.71 | OPRM1 (0.48) | OPRM1OPRK1OPRL1HTR1DHTR1B | |
| SCHEMBL6596961 | 0.70 | OPRM1 (0.45) | OPRM1OPRK1OPRL1POLBHTR1D | |
| SCHEMBL6597200 | 0.70 | OPRM1 (0.49) | OPRM1OPRK1OPRL1KDM4EHTR1D | |
| Hydrochloric Acid SCHEMBL7868006 | 0.70 | OPRM1 (0.62) | OPRM1OPRK1OPRL1SLC6A4KDM4E | |
| SCHEMBL6595053 | 0.70 | HTR1D (0.49) | OPRM1OPRK1OPRL1HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1264838-C | Indole derivatives for treating central nervous system disease | LUNDBECK & CO AS H (DK) | 2006-07-19 | — | — | CN | disclosed |
| US-6743809-B2 | Indole Derivatives useful for the treatment of CNS disorders | H. LUNDBECK A/S (DK) | 2004-06-01 | — | — | US | disclosed |
| EP-1305307-B1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | LUNDBECK & CO AS H (DK) | 2004-05-06 | — | — | EP | disclosed |
| CN-1451002-A | Indole derivatives for treating central nervous system disease | LUNDBECK & CO AS H (DK) | 2003-10-22 | — | — | CN | disclosed |
| US-20030166664-A1 | Indole derivatives useful for the treatment of CNS disorders | H. LUNDBECK A/S (DK) | 2003-09-04 | — | — | US | disclosed |
| EP-1305307-A1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. Lundbeck A/S (DK) | 2003-05-02 | — | — | EP | disclosed |
| WO-2002008223-A1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. LUNDBECK A/S (DK) | 2002-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166664-A1 | Indole derivatives useful for the treatment of CNS disorders | DRD2, DRD3, CNR1 | OPRM1 61/4885OPRK1 33/4885OPRL1 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.