Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6593968 | 0.92 | OPRM1 (0.54) | OPRM1OPRK1OPRL1HTR6KCNH2 | |
| SCHEMBL6598131 | 0.91 | SLC6A4 (0.49) | OPRM1OPRK1OPRL1HTR6KCNH2 | |
| SCHEMBL6596780 | 0.84 | HTR1D (0.56) | OPRM1OPRK1OPRL1HTR6KCNH2 | |
| SCHEMBL27537908 | 0.78 | OPRM1 (0.50) | OPRM1OPRK1OPRL1HTR6KCNH2 | |
| SCHEMBL27541443 | 0.77 | APP (0.50) | OPRM1OPRK1OPRL1HTR6KCNH2 | |
| SCHEMBL6598134 | 0.77 | HTR1D (0.50) | OPRM1OPRK1OPRL1DRD2HTR1D | |
| SCHEMBL31143224 | 0.77 | ADRA1D (0.57) | OPRM1OPRK1OPRL1HTR6KCNH2 | |
| SCHEMBL6598294 | 0.76 | HTR1D (0.45) | SLC6A4DRD2HTR1DHTR1BCCR2 | |
| SCHEMBL6595114 | 0.76 | OPRM1 (0.48) | OPRM1OPRK1OPRL1DRD2HTR1D | |
| SCHEMBL6598237 | 0.76 | OPRM1 (0.47) | OPRM1OPRK1OPRL1SLC6A4HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1305307-A1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. Lundbeck A/S (DK) | 2003-05-02 | — | — | EP | disclosed |
| WO-2002008223-A1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. LUNDBECK A/S (DK) | 2002-01-31 | — | — | WO | disclosed |