Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 14/20 | 0.42 |
| ▸ | CA1 | P00915 | 12/20 | 0.42 |
| ▸ | CA9 | Q16790 | 8/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 5/20 | 0.38 |
| ▸ | CCR2 | P41597 | 2/20 | 0.37 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA6 | P23280 | 2/20 | 0.36 |
| ▸ | CA5A | P35218 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4575696 | 0.83 | PTGS1 (0.56) | CA2CA1CA9PTGS1PTGS2 | |
| SCHEMBL8098906 | 0.81 | PTGS1 (0.43) | CA2CA1CA9PTGS1PTGS2 | |
| SCHEMBL8101068 | 0.80 | PTGS1 (0.43) | CA2CA1CA9PTGS1PTGS2 | |
| SCHEMBL8107827 | 0.79 | CA2 (0.48) | CA2CA1CA9PTGS1PTGS2 | |
| SCHEMBL8107826 | 0.78 | CA2 (0.42) | CA2CA1CA9PTGS1PTGS2 | |
| SCHEMBL8099469 | 0.78 | CA2 (0.63) | CA2CA1CA9PTGS1PTGS2 | |
| SCHEMBL8481841 | 0.78 | CA2 (0.63) | CA2CA1CA9PTGS1PTGS2 | |
| SCHEMBL7067324 | 0.78 | CA2 (0.41) | CA2CA1CA9PTGS1PTGS2 | |
| SCHEMBL8481837 | 0.77 | CA2 (0.62) | CA2CA1CA9PTGS1PTGS2 | |
| SCHEMBL8100682 | 0.77 | PTGES2 (0.42) | CA2CA1CA9PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414526-A2 | ANTIANGIOGENIC COMBINATION THERAPY FOR THE TREATMENT OF CANCER | Pharmacia Corporation (US) | 2004-05-06 | — | — | EP | claimed |
| WO-2002085459-A2 | ANTIANGIOGENIC COMBINATION THERAPY FOR THE TREATMENT OF CANCER | PHARMACIA CORPORATION (US) | 2002-10-31 | — | — | WO | claimed |