SCHEMBL4575696

SCHEMBL4575696

CS(=O)(=O)Nc1ccc(S(N)(=O)=O)cc1Sc1ccc(Cl)cc1Cl

nearest known ligand 0.56

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 2/20 0.56
PTGS2 P35354 2/20 0.56
CA2 P00918 11/20 0.43
CA1 P00915 9/20 0.43
CA9 Q16790 5/20 0.43
ITGB2 P05107 1/20 0.41
ICAM1 P05362 1/20 0.41
ITGAL P20701 1/20 0.41
CCR2 P41597 4/20 0.41
CA12 O43570 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8098762 0.90 PTGS1 (0.45) PTGS1PTGS2CA2CA1CA9
SCHEMBL8092090 0.89 PTGS2 (0.44) PTGS1PTGS2CA2CA1CA9
SCHEMBL8091883 0.89 PTGS1 (0.44) PTGS1PTGS2CA2CA1CA9
SCHEMBL8479236 0.89 PTGS1 (0.44) PTGS1PTGS2CA2CA1CA9
SCHEMBL8098906 0.88 PTGS1 (0.43) PTGS1PTGS2CA2CA1CA9
SCHEMBL8101068 0.87 PTGS1 (0.43) PTGS1PTGS2CA2CA1CA9
SCHEMBL8101100 0.86 CA2 (0.44) PTGS1PTGS2CA2CA1CA9
SCHEMBL8101110 0.86 CA2 (0.44) PTGS1PTGS2CA2CA1CA9
SCHEMBL8107827 0.85 CA2 (0.48) PTGS1PTGS2CA2CA1CA9
SCHEMBL8107826 0.85 CA2 (0.42) PTGS1PTGS2CA2CA1CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1414526-A2 ANTIANGIOGENIC COMBINATION THERAPY FOR THE TREATMENT OF CANCER Pharmacia Corporation (US) 2004-05-06 EP claimed
EP-1377298-A2 COMBINED METHOD FOR TREATING HORMONO-DEPENDENT DISORDERS Pharmacia Italia S.p.A. (IT) 2004-01-07 EP claimed
US-20030087942-A1 Method for the treatment and prevention of cachexia WASHINGTON UNIVERSITY 2003-05-08 US claimed
WO-2003020268-A1 METHOD FOR THE TREATMENT AND PREVENTION OF CACHEXIA WASHINGTON UNIVERSITY (US) 2003-03-13 WO claimed
WO-2002085459-A2 ANTIANGIOGENIC COMBINATION THERAPY FOR THE TREATMENT OF CANCER PHARMACIA CORPORATION (US) 2002-10-31 WO claimed
WO-2002072106-A2 COMBINED METHOD FOR TREATING HORMONO-DEPENDENT DISORDERS WITH EXEMESTANE PHARMACIA ITALIA SPA (IT) 2002-09-19 WO claimed
US-20020103141-A1 Antiangiogenic combination therapy for the treatment of cancer PHARMACIA CORPORATION 2002-08-01 US claimed
EP-1140194-A2 USE OF CYCLOOXYGENASE-2 INHIBITOR, A MATRIX METALLAPROTEINASE INHIBITOR, AN ANTINEOPLASTIC AGENT AND OPTIONALLY RADIATION AS A COMBINED TREATMENT OF NEOPLASIA G.D. SEARLE & CO. (US) 2001-10-10 EP claimed
EP-1140192-A2 USE OF A CYCLOOXYGENASE-2 INHIBITOR AND ONE OR MORE ANTINEOPLASTIC AGENTS FOR COMBINATION THERAPY IN NEOPLASIA G.D. SEARLE & CO. (US) 2001-10-10 EP claimed
EP-1140179-A2 USE OF A CYCLOOXYGENASE 2 INHIBITOR AND AN INTEGRIN ANTAGONIST AS A COMBINATION THERAPY IN THE TREATMENT OF NEOPLASIA G.D. SEARLE & CO. (US) 2001-10-10 EP claimed
WO-2000038730-A2 USE OF A CYCLOOXYGENASE-2 INHIBITOR AND ONE OR MORE ANTINEOPLASTIC AGENTS FOR COMBINATION THERAPY IN NEOPLASIA G.D. SEARLE & CO. (US) 2000-07-06 WO claimed
WO-2000038786-A2 USE OF CYCLOOXYGENASE 2 INHIBITOR AND AN INTEGRIN ANTAGONIST AS A COMBINATION THERAPY IN THE TREATMENT OF NEOPLASIA G.D. SEARLE & CO. (US) 2000-07-06 WO claimed
WO-2000037107-A2 USE OF CYCLOOXYGENASE-2 INHIBITOR, A MATRIX METALLAPROTEINASE INHIBITOR, AN ANTINEOPLASTIC AGENT AND OPTIONALLY RADIATION AS A COMBINATION TREATMENT OF NEOPLASIA G.D. SEARLE & CO. (US) 2000-06-29 WO claimed
US-20260027079-A1 CANNABINOID ACID ESTER COMPOSITIONS AND USES THEREOF EPM IP INC (US) 2026-01-29 US disclosed
US-20230202964-A1 CANNABIGEROLIC ACID (CDGA) DERIVATIVES AND USES THEREOF YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2023-06-29 US disclosed
US-20230192588-A1 CANNABIDIOLIC ACID (CBDA) DERIVATIVES AND USES THEREOF YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2023-06-22 US disclosed
EP-1140194-A2 USE OF CYCLOOXYGENASE-2 INHIBITOR, A MATRIX METALLAPROTEINASE INHIBITOR, AN ANTINEOPLASTIC AGENT AND OPTIONALLY RADIATION AS A COMBINED TREATMENT OF NEOPLASIA G.D. SEARLE & CO. (US) 2001-10-10 EP disclosed
WO-2001000229-A1 COMBINATION OF TUMORS NECROCIS FACTOR (TNF) ANTAGONISTS AND COX-2 INHIBITORS FOR THE TREATMENT OF INFLAMMATION PHARMACIA CORPORATION (US) 2001-01-04 WO disclosed
WO-2000038730-A2 USE OF A CYCLOOXYGENASE-2 INHIBITOR AND ONE OR MORE ANTINEOPLASTIC AGENTS FOR COMBINATION THERAPY IN NEOPLASIA G.D. SEARLE & CO. (US) 2000-07-06 WO disclosed
WO-2000037107-A2 USE OF CYCLOOXYGENASE-2 INHIBITOR, A MATRIX METALLAPROTEINASE INHIBITOR, AN ANTINEOPLASTIC AGENT AND OPTIONALLY RADIATION AS A COMBINATION TREATMENT OF NEOPLASIA G.D. SEARLE & CO. (US) 2000-06-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230192588-A1 CANNABIDIOLIC ACID (CBDA) DERIVATIVES AND USES THEREOF CNR2, CNR1, GPR18 PTGS1 1885/4885PTGS2 1908/4885CA2 3047/4885
US-20020103141-A1 Antiangiogenic combination therapy for the treatment of cancer TOP2A, TOP2B, TOP1 PTGS1 6/4885PTGS2 4/4885CA2 85/4885
US-20030087942-A1 Method for the treatment and prevention of cachexia TNF, PTGES2, PTGS2 PTGS1 4/4885PTGS2 3/4885CA2 685/4885
US-20260027079-A1 CANNABINOID ACID ESTER COMPOSITIONS AND USES THEREOF CNR2, CNR1, FAAH PTGS1 2010/4885PTGS2 2555/4885CA2 2866/4885
US-20230202964-A1 CANNABIGEROLIC ACID (CDGA) DERIVATIVES AND USES THEREOF CNR2, CNR1, GPR18 PTGS1 495/4885PTGS2 411/4885CA2 2025/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.