Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 5/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.40 |
| ▸ | CLK2 | P49760 | 3/20 | 0.40 |
| ▸ | CLK3 | P49761 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.40 |
| ▸ | DYRK4 | Q9NR20 | 3/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582670 | 0.81 | DYRK1A (0.45) | DYRK1ANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL25022821 | 0.81 | DYRK1A (0.45) | DYRK1ANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL8058511 | 0.81 | DYRK1A (0.45) | DYRK1ANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL13353670 | 0.78 | DYRK1A (0.42) | DYRK1ANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27629454 | 0.78 | LMNA (0.46) | DYRK1ANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL926971 | 0.74 | DYRK1A (0.49) | DYRK1ANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL24425916 | 0.73 | DYRK1A (0.72) | DYRK1ANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL2603491 | 0.72 | EGFR (0.51) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL116288 | 0.69 | DYRK1A (0.58) | DYRK1ANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1586683 | 0.69 | DYRK1A (0.49) | DYRK1ANPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385833-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | Amgen Inc. (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002083654-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |