SCHEMBL116288

SCHEMBL116288

Nc1ccc2ncoc2c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 3/20 0.58
KMT2A Q03164 4/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
KDM4E B2RXH2 3/20 0.43
MAPT P10636 3/20 0.43
ALDH1A1 P00352 3/20 0.43
MEN1 O00255 3/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
GAA P10253 2/20 0.43
GLA P06280 1/20 0.43
HPGD P15428 1/20 0.43
LMNA P02545 2/20 0.41
ATM Q13315 2/20 0.39
HTT P42858 2/20 0.39
TP53 P04637 1/20 0.39
HSP90AA1 P07900 1/20 0.39
HSP90AB1 P08238 1/20 0.39
TSHR P16473 1/20 0.39
CASP1 P29466 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL115366 0.83 DYRK1A (0.58) DYRK1AKMT2ASMN1; SMN2KDM4EMAPT
SCHEMBL29361664 0.83 DYRK1A (0.58) DYRK1AKMT2ASMN1; SMN2KDM4EMAPT
Hydrochloric Acid SCHEMBL28263323 0.81 DYRK1A (0.56) DYRK1AKMT2ASMN1; SMN2KDM4EMAPT
SCHEMBL28180691 0.80 DYRK1A (0.41) DYRK1AKMT2ASMN1; SMN2KDM4EMAPT
SCHEMBL24425916 0.77 DYRK1A (0.72) DYRK1AKMT2ASMN1; SMN2ALDH1A1MEN1
Benzo[D]Oxazole SCHEMBL28373722 0.77 NPC1 (0.46) DYRK1AKMT2ASMN1; SMN2KDM4EMAPT
Hydrazine SCHEMBL27569854 0.75 DYRK1A (0.50) DYRK1AKMT2ASMN1; SMN2KDM4EMAPT
SCHEMBL926971 0.74 DYRK1A (0.49) DYRK1AKMT2ASMN1; SMN2KDM4EMAPT
SCHEMBL1798498 0.74 DYRK1A (0.49) DYRK1AKMT2ASMN1; SMN2KDM4EALDH1A1
SCHEMBL3092188 0.74 DYRK1A (0.49) DYRK1AKMT2ASMN1; SMN2ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 314 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118955769-B Gold-based catalyst for polyvinyl chloride production and preparation method and application thereof 南开大学 2025-01-10 CN claimed
CN-118955769-A Gold-based catalyst for polyvinyl chloride production and preparation method and application thereof 南开大学 2024-11-15 CN claimed
CN-115368255-B Anthraquinone diamine monomer, cyan intrinsic polyimide derived from anthraquinone diamine monomer and preparation method of cyan intrinsic polyimide 上海交通大学 2024-06-25 CN claimed
CN-117534834-A Polymer, preparation method and application thereof, and intrinsic low-temperature curing negative photoresist 上海交通大学 2024-02-09 CN claimed
CN-112384546-B Thermally conductive resin composition 东洋纺株式会社 2024-01-16 CN claimed
CN-116874885-A Polyarylether grafted carbon nano tube containing heterocyclic structure and continuous fiber reinforced thermoplastic resin matrix composite material thereof 大连理工大学 2023-10-13 CN claimed
CN-116836384-A Polymer for black matrix, preparation method and application thereof 上海交通大学 2023-10-03 CN claimed
CN-115197082-B Anthraquinone diamine monomer, magenta intrinsic polyimide derived from anthraquinone diamine monomer and preparation method of magenta intrinsic polyimide 上海交通大学 2023-09-22 CN claimed
CN-115232303-B Polymer for black matrix, preparation method and application thereof 上海交通大学 2023-09-15 CN claimed
US-20260138990-A1 TRICYCLIC FUSED IMIDAZOLE COMPOUNDS AS CD38 MODULATORS AND USES THEREOF AEOVIAN PHARMACEUTICALS INC (US) 2026-05-21 US disclosed
EP-4737445-A1 NOVEL SATURATED HETEROCYCLE-SUBSTITUTED HETEROARYL-CARBONOHYDRAZONOYL DICYANIDE COMPOUND AND USE THEREOF Korea Institute of Science and Technology (KR) 2026-05-06 EP disclosed
US-20260103446-A1 CFTR REGULATORS AND METHODS OF USE THEREOF UNIV CALIFORNIA (US) 2026-04-16 US disclosed
EP-4702026-A1 TRICYCLIC FUSED IMIDAZOLE COMPOUNDS AS CD38 MODULATORS AND USES THEREOF Aeovian Pharmaceuticals, Inc. (US) 2026-03-04 EP disclosed
EP-4019501-B1 CFTR REGULATORS AND METHODS OF USE THEREOF UNIV CALIFORNIA (US) 2026-02-04 EP disclosed
US-20050101604-A1 Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of bruton's tyrosine kinase by such compounds GILEAD CONNECTICUT, INC. 2005-05-12 US disclosed
WO-2005005429-A1 CERTAIN HETEROCYCLIC SUBSTITUTED IMIDAZO[1,2-A]PYRAZIN-8-YLAMINES AND METHODS OF INHIBITION OF BRUTON’S TYROSINE KINASE BY SUCH COMPOUNDS CELLULAR GENOMICS, INC. (US) 2005-01-20 WO disclosed
EP-1463714-A2 VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS Amgen Inc. (US) 2004-10-06 EP disclosed
US-20030195201-A1 Vanilloid receptor ligands and their use in treatments AMGEN INC. 2003-10-16 US disclosed
WO-2003049702-A2 VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS AMGEN INC. (US) 2003-06-19 WO disclosed
US-5057526-A Immunological disorders, suppress organ rejection BOEHRINGER MANNHEIM GMBH (DE) 1991-10-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260138990-A1 TRICYCLIC FUSED IMIDAZOLE COMPOUNDS AS CD38 MODULATORS AND USES THEREOF CD38, BCL9, BCL6B DYRK1A 2437/4885KMT2A 2357/4885SMN1; SMN2 2466/4885
US-20030195201-A1 Vanilloid receptor ligands and their use in treatments TRPV1, TRPV2, TRPV3 DYRK1A 1421/4885KMT2A 3770/4885SMN1; SMN2 2292/4885
US-20050101604-A1 Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of bruton's tyrosine kinase by such compounds BTK, SYK, LYN DYRK1A 400/4885KMT2A 733/4885SMN1; SMN2 1459/4885
US-20260103446-A1 CFTR REGULATORS AND METHODS OF USE THEREOF CFTR, CLCN2, SLC26A3 DYRK1A 1109/4885KMT2A 4408/4885SMN1; SMN2 3549/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.