Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3441616 | 0.86 | L3MBTL1 (0.52) | MRGPRX4MTORKMT2AMAPK1RAB9A | |
| SCHEMBL3195037 | 0.83 | RAB9A (0.56) | KMT2ARAB9ACES2CES1MEN1 | |
| SCHEMBL6600122 | 0.82 | MAPK1 (0.38) | MRGPRX4MTORHPGDSKMT2AMAPK1 | |
| SCHEMBL6600125 | 0.82 | MAPK1 (0.38) | MRGPRX4MTORHPGDSKMT2AMAPK1 | |
| SCHEMBL6599217 | 0.77 | KMT2A (0.42) | KMT2AMEN1LMNAMAPTHPGD | |
| SCHEMBL8298172 | 0.77 | RAB9A (0.55) | KMT2ARAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL4051434 | 0.74 | RAB9A (0.48) | KMT2ARAB9ACES2CES1CTNNB1 | |
| SCHEMBL19555418 | 0.74 | KMT2A (0.54) | MRGPRX4KMT2ARAB9AKDM4ENPC1 | |
| SCHEMBL3282343 | 0.72 | CES2 (0.54) | MRGPRX4KMT2ACES2CTNNB1WNT3A | |
| SCHEMBL2309516 | 0.72 | KMT2A (0.62) | KMT2AMAPK1RAB9AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756498-B2 | REARRANGEMENT OF AZIRINE COMPOUND OR PROTECTED DERIVATIVE THEREOF IN PRESENCE OF TRANSITION METAL CATALYST AND SOLVENT TO PRODUCE PYRAZOLOPYRIDINE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2004-06-29 | — | — | US | disclosed |
| EP-1276742-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2004-06-09 | — | — | EP | disclosed |
| US-20030212275-A1 | PROCESS FOR THE PREPARATION OF CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2003-11-13 | — | — | US | disclosed |
| EP-1276742-A2 | PROCESS FOR THE PREPARATION OF PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001083479-A2 | PROCESS FOR THE PREPARATION OF PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212275-A1 | PROCESS FOR THE PREPARATION OF CHEMICAL COMPOUNDS | CBR1, C1R, CBR3 | MRGPRX4 1737/4885MTOR 3690/4885HPGDS 3033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.