Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598919 | 1.00 | S1PR1 (0.36) | S1PR1LTB4RLTB4R2MEN1KMT2A | |
| SCHEMBL6599513 | 0.93 | S1PR1 (0.35) | S1PR1LTB4RPLA2G2AS1PR3THRA | |
| SCHEMBL6598501 | 0.90 | PLA2G2A (0.38) | S1PR1PLA2G2AS1PR3THRATHRB | |
| SCHEMBL6601202 | 0.86 | S1PR1 (0.39) | S1PR1PLA2G2AS1PR3THRATHRB | |
| SCHEMBL6597512 | 0.85 | PLA2G2A (0.37) | S1PR1PLA2G2AS1PR3THRATHRB | |
| SCHEMBL5808071 | 0.84 | LTB4R (0.34) | S1PR1LTB4RLTB4R2MEN1KMT2A | |
| SCHEMBL5808083 | 0.84 | LTB4R (0.34) | S1PR1LTB4RLTB4R2MEN1KMT2A | |
| SCHEMBL5812485 | 0.83 | LTB4R (0.34) | LTB4RLTB4R2MEN1KMT2APLA2G2A | |
| SCHEMBL5812476 | 0.83 | LTB4R (0.34) | LTB4RLTB4R2MEN1KMT2APLA2G2A | |
| SCHEMBL6603373 | 0.81 | PPARD (0.44) | LTB4RLTB4R2PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170009-B1 | Thiazolybenzofuran derivatives and their use as SRS-A and leukotiene antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-04-07 | — | — | EP | disclosed |
| EP-1170009-A2 | Thiazolybenzofuran derivatives and their use as SRS-A and leukotiene antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-01-09 | — | — | EP | disclosed |
| US-5994378-A | ANTIALLERGENS; ANTIINFLAMMATORY AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-11-30 | — | — | US | disclosed |