Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7036663 | 0.85 | HRH3 (0.43) | HRH3SLC18A3MAPTLMNAPOLB | |
| SCHEMBL15820429 | 0.77 | HRH3 (0.40) | HRH3LMNAGAAALDH1A1 | |
| SCHEMBL5261631 | 0.77 | HRH3 (0.45) | HRH3SLC18A3MAPTGAAALDH1A1 | |
| SCHEMBL16881226 | 0.76 | CYP2C9 (0.41) | LMNA | |
| SCHEMBL1877250 | 0.74 | SLC18A3 (0.44) | HRH3SLC18A3MAPTLMNAPOLB | |
| SCHEMBL16880537 | 0.73 | CFB (0.43) | HRH3 | |
| SCHEMBL4014807 | 0.73 | HRH3 (0.40) | HRH3MAPTLMNAGAAALDH1A1 | |
| SCHEMBL1581647 | 0.72 | SLC18A3 (0.48) | SLC18A3MAPTLMNAPOLBGAA | |
| SCHEMBL6599138 | 0.71 | SLC18A3 (0.47) | SLC18A3MAPTLMNAALDH1A1 | |
| SCHEMBL9252161 | 0.71 | ALDH1A1 (0.43) | HRH3SLC18A3MAPTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430048-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | Allergan, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003027102-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2003-04-03 | — | — | WO | disclosed |