Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1581647 | 0.87 | SLC18A3 (0.48) | SLC18A3ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL28539303 | 0.83 | RIPK1 (0.47) | SLC18A3ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL29068350 | 0.82 | CYP1A2 (0.57) | ALDH1A1LMNAHPGDKMT2AMAPT | |
| SCHEMBL28408689 | 0.82 | ALDH1A1 (0.54) | ALDH1A1LMNAHPGDKMT2AMAPT | |
| SCHEMBL17548235 | 0.80 | RIPK1 (0.46) | ALDH1A1HPGD | |
| SCHEMBL9336982 | 0.79 | RIPK1 (0.63) | — | |
| SCHEMBL25279026 | 0.79 | ALDH1A1 (0.54) | SLC18A3ALDH1A1LMNAPKMKMT2A | |
| SCHEMBL7230204 | 0.78 | ADRB1 (0.44) | SLC18A3ALDH1A1PKMHPGDCA1 | |
| SCHEMBL1922839 | 0.76 | GCK (0.45) | ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL1922838 | 0.76 | GCK (0.45) | ALDH1A1LMNAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430048-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | Allergan, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003027102-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2003-04-03 | — | — | WO | disclosed |