SCHEMBL6599306

SCHEMBL6599306

OC([CH]c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.42
CYP1A2 P05177 3/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 1/20 0.38
ALDH1A1 P00352 7/20 0.36
TSHR P16473 3/20 0.36
KCNN4 O15554 1/20 0.36
MAOB P27338 1/20 0.36
CYP2A6 P11509 1/20 0.36
LMNA P02545 3/20 0.36
MAPT P10636 2/20 0.36
S1PR4 O95977 1/20 0.36
S1PR1 P21453 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
HDAC3 O15379 1/20 0.34
TNKS O95271 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34
HCAR2 Q8TDS4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4630824 0.76 KDM4E (0.48) KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL4630827 0.76 KDM4E (0.48) KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL3906029 0.76 KDM4E (0.57) KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL3906030 0.76 KDM4E (0.57) KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL2782027 0.74 ALDH1A1 (0.39) CYP1A2ALDH1A1TSHRKCNN4MAOB
SCHEMBL28901983 0.72 ALDH1A1 (0.38) CYP1A2ALDH1A1TSHRKCNN4MAOB
SCHEMBL4887210 0.72 KDM4E (0.48) KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL6130600 0.72 CYP2C19 (0.41) CYP1A2CYP2C9CYP2C19ALDH1A1TSHR
SCHEMBL863162 0.72 KDM4E (0.44) KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL17629414 0.72 CYP2C19 (0.41) CYP1A2CYP2C9CYP2C19ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1080082-B1 INTERMEDIATES FOR THE SYNTHESIS OF EPOTHILONES AND METHODS FOR THEIR PREPARATION NOVARTIS AG (CH) 2004-10-06 EP disclosed
US-6350878-B1 BASIFICATION AND IODINATION OF ALDEHYDE NOVARTIS AG (CH) 2002-02-26 US disclosed
US-5246960-A Used to treat obesity, hyperlipaemia, atherosclerosis and arteriosclerosis HOFFMANN-LA ROCHE INC. (US) 1993-09-21 US disclosed
US-5175186-A Inhibits pancreas lepase and useful agent in treatment of obesity, hyperlipemia, atherosclerosis and arteriosclerosis HOFFMANN-LA ROCHE INC. (US) 1992-12-29 US disclosed
US-5120848-A Anticholesterol and antilipemic agents; hydroxy-3-methylglutaryl/3-/ coenzyme A reductase inhibitors GLAXO GROUP LIMITED (GB) 1992-06-09 US disclosed
US-5110940-A Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase BRISTOL-MYERS COMPANY (US) 1992-05-05 US disclosed
WO-1991018903-A1 PYRROLOPYRIDAZINE COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1991-12-12 WO disclosed
US-5068346-A Anticholesterol agents BRISTOL-MYERS COMPANY (US) 1991-11-26 US disclosed
CN-1012643-B Preparation method of epoxypropane ketone compound HOFFMANN LA ROCHE (CH) 1991-05-22 CN disclosed
US-4983746-A Oxetanones and process for their production HOFFMANN-LA ROCHE INC. (US) 1991-01-08 US disclosed
US-4931463-A PANCREAS LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 1990-06-05 US disclosed
US-4897490-A DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE BRISTOL-MEYERS COMPANY (US) 1990-01-30 US disclosed
WO-1988006584-A1 ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS BRISTOL-MYERS COMPANY (US) 1988-09-07 WO disclosed
CN-85108888-A The preparation method of propylene oxide ketone compounds 1986-07-09 CN disclosed